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Plos One : Lats2 Modulates Adipocyte Proliferation and Differentia...

By: Hong Wanjin

Description : First identified in Drosophila and highly conserved in mammals, the Hippo pathway controls organ size. Lats2 is one of the core kinases of the Hippo pathway and plays major roles in cell proliferation by interacting with the downstream transcriptional cofactors YAP and TAZ. Although the function of the Hippo pathway and Lats2 is relatively well understood in several tissues and organs, less is known about the function of Lats2 and Hippo signaling in adipose...

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Plos One : Investigation of the Interaction of Naringin Palmitate ...

By: Hasan Rizwan Khan

Description : In conclusion, naringin palmitate was transported by BSA and was easily removed afterwards. As a consequence, an extension of naringin applications for use in food, cosmetic and medicinal preparations may be clinically and practically significant, especially in the design of new naringin palmitate-inspired drugs.

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Plos One : a Further Analysis of the Relationship Between Yellow R...

By: Luis Herrera-estrella

Description : Mature pepper (Capsicum sp.) fruits come in a variety of colors, including red, orange, yellow, brown, and white. To better understand the genetic and regulatory relationships between the yellow fruit phenotype and the capsanthin-capsorubin synthase gene (Ccs), we examined 156 Capsicum varieties, most of which were collected from Northwest Chinese landraces. A new ccs variant was identified in the yellow fruit cultivar CK7. Cluster analysis revealed that CK...

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Plos One : Comparison of Ihc, Fish and Rt-pcr Methods for Detectio...

By: Syed A. Aziz

Description : Among the three detection methods, RT-PCR could detect not only the presence of EML4-ALK fusion gene and their variant types, but also the abundance of EML4-ALK positive cells in NSCLC tumor tissues. The latter two factors might affect the treatment response to anti-ALK inhibitor. Including RT-PCR as a diagnostic test for ALK inhibitor treatment in the prospective clinical trials is recommended

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Plos One : Uroplakin Peptide-specific Autoimmunity Initiates Inter...

By: Wasif N. Khan

Description : The pathophysiology of interstitial cystitis/painful bladder syndrome (IC/PBS) is enigmatic. Autoimmunity and impaired urothelium might lead the underlying pathology. A major shortcoming in IC/PBS research has been the lack of an appropriate animal model. In this study, we show that the bladder specific uroplakin 3A-derived immunogenic peptide UPK3A 65–84, which contains the binding motif for IAd MHC class II molecules expressed in BALB/c mice, is capable o...

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Plos One : Development of Models for Predicting the Predominant Ta...

By: Inés Álvarez

Description : Taste and odor (T&O) problems, which have adversely affected the quality of water supplied to millions of residents, have repeatedly occurred in Taihu Lake (e.g., a serious odor accident occurred in 2007). Because these accidents are difficult for water resource managers to forecast in a timely manner, there is an urgent need to develop optimum models to predict these T&O problems. For this purpose, various biotic and abiotic environmental parameters were m...

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Plos One : Morphology of the Epidermis of the Neotropical Catfish ...

By: Michael Koval

Description : The epidermis of Ostariophysi fish is composed of 4 main cell types : epidermal cells (or filament containing cells), mucous cells, granular cells and club cells. The morphological analysis of the epidermis of the catfish Pimelodella lateristriga revealed the presence of only two types of cells : epidermal and club cells. The latter were evident in the middle layer of the epidermis, being the largest cells within the epithelium. Few organelles were located ...

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Plos One : Expression and Significance of Neuroligins in Myenteric...

By: Anthony W.I. Lo

Description : Neuroligins were expressed in ICC-MY of human beings, and the expression varies from different segments of HSCR. This abnormal expression might play an important role in the pathogenesis of this disease through affecting the synaptic function of ICC-MY.

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Plos One : an Integrated Approach for Identifying Wrongly Labelled...

By: Philippe Rouet

Description : We tackle the outlier detection problem based on a previously proposed Multiple-Filter-Multiple-Wrapper (MFMW) model, which was demonstrated to yield promising results when compared to other hybrid approaches (Leung and Hung, 2010). To incorporate outlier detection and overcome limitations of the existing MFMW model, three new features are introduced in our proposed MFMW-outlier approach : 1) an unbiased external Leave-One-Out Cross-Validation framework is ...

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Plos One : Getting a Grip on Memory ; Unilateral Hand Clenching Al...

By: Lesley Joy Rogers

Description : Unilateral hand clenching increases neuronal activity in the frontal lobe of the contralateral hemisphere. Such hand clenching is also associated with increased experiencing of a given hemisphere’s ‘‘mode of processing.’’ Together, these findings suggest that unilateral hand clenching can be used to test hypotheses concerning the specializations of the cerebral hemispheres during memory encoding and retrieval. We investigated this possibility by testing eff...

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Plos One : Fenretinide Corrects the Imbalance Between Omega-6 to O...

By: Abhay R Satoskar

Description : We previously identified Fragile X-related protein 1 (FXR1) as an RNA-binding protein involved in the post-transcriptional control of TNF and other cytokines in macrophages. Macrophages derived from FXR1-KO mice overexpress several inflammatory cytokines including TNF. Recently, we showed that fenretinide (4HPR) is able to inhibit several inflammatory cytokines in the lungs of cystic fibrosis mice, which also have abnormal immune responses. Therefore, we hy...

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Plos One : Hypovitaminosis D is Independently Associated with Meta...

By: Guoying Wang

Description : A powerful association exists between hypovitaminosis D and MS in obese patients independently from body fat mass and its clinical correlates. This indicates that the association between low 25(OH) D3 levels and MS is not merely induced by vitamin D deposition in fat tissue and reinforces the hypothesis that hypovitaminosis D represent a crucial independent determinant of MS.

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Plos One : Serum Can Overcome Contact Inhibition in Confluent Huma...

By: Gianfranco Pintus

Description : Pulmonary artery endothelial cells (PAEC) in an intact vessel are continually exposed to serum, but unless injured, do not proliferate, constrained by confluence. In contrast, pulmonary artery smooth muscle cells (PASMC) attain, and maintain, confluence in the presence of minimal serum, protected from serum’s stimulatory effects except when the endothelial barrier becomes more permeable. We hypothesized therefore, that confluent PASMC may be less constraine...

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Plos One : Metabolic Rate Regulates L1 Longevity in C. Elegans, Vo...

By: Patrick Callaerts

Description : Animals have to cope with starvation. The molecular mechanisms by which animals survive long-term starvation, however, are not clearly understood. When they hatch without food, C. elegans arrests development at the first larval stage (L1) and survives more than two weeks. Here we show that the survival span of arrested L1s, which we call L1 longevity, is a starvation response regulated by metabolic rate during starvation. A high rate of metabolism shortens ...

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Plos One : Publication Bias in Laboratory Animal Research ; a Surv...

By: Erik Von Elm

Description : Context : Publication bias jeopardizes evidence-based medicine, mainly through biased literature syntheses. Publication bias may also affect laboratory animal research, but evidence is scarce. Objectives : To assess the opinion of laboratory animal researchers on the magnitude, drivers, consequences and potential solutions for publication bias. And to explore the impact of size of the animals used, seniority of the respondent, working in a for-profit organi...

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Plos One : Effect of Blue Light on Endogenous Isopentenyladenine a...

By: Miguel A. Blazquez

Description : Light is one of the most important factor influencing plant growth and development all through their life cycle. One of the well-known light-regulated processes is de-etiolation, i.e. the switch from skotomorphogenesis to photomorphogenesis. The hormones cytokinins (CKs) play an important role during the establishment of photomorphogenesis as exogenous CKs induced photomorphogenesis of dark-grown seedlings. Most of the studies are conducted on the plant mod...

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Plos One : Population-based 5-year Follow-up Study in Taiwan of De...

By: Weili Zhang

Description : Dementia may be an independent risk factor for stroke, and the use of antipsychotics may further increase the risk of stroke in dementia patients

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Plos One : Cell Biological Characterization of the Malaria Vaccine...

By: Erika Martins Braga

Description : In a genome-wide screen for alpha-helical coiled coil motifs aiming at structurally defined vaccine candidates we identified PFF0165c. This protein is exported in the trophozoite stage and was named accordingly Trophozoite exported protein 1 (Tex1). In an extensive preclinical evaluation of its coiled coil peptides Tex1 was identified as promising novel malaria vaccine candidate providing the rational for a comprehensive cell biological characterization of ...

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Plos One : Assessing the Spatial Scale Effect of Anthropogenic Fac...

By: Diego Fontaneto

Description : Patch context is a way to describe the effect that the surroundings exert on a landscape patch. Despite anthropogenic context alteration may affect species distributions by reducing the accessibility to suitable patches, species distribution modelling have rarely accounted for its effects explicitly. We propose a general framework to statistically detect the occurrence and the extent of such a factor, by combining presence-only data, spatial distribution mo...

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Plos One : Climate and Demography Dictate the Strength of Predator...

By: Christopher Fulton

Description : There is growing evidence that climate and anthropogenic influences on marine ecosystems are largely manifested by changes in species spatial dynamics. However, less is known about how shifts in species distributions might alter predatorprey overlap and the dynamics of prey populations. We developed a general approach to quantify species spatial overlap and identify the biotic and abiotic variables that dictate the strength of overlap. We used this method t...

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