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Plos One : If You’ve Got It, Flaunt it ; Humans Flaunt Attractive ...

By: Ian D. Stephen

Description : Mating decisions are influenced by conspecifics’ mate choices in many species including humans. Recent research has shown that women are more attracted to men with attractive putative partners than those with less attractive partners. We integrate these findings with traditional accounts of social signaling and test five hypotheses derived from it. In our study, 64 men and 75 women were paired with attractive and unattractive opposite-sex putative partners ...

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Plos One : Comparative Spatial Dynamics of Japanese Encephalitis a...

By: Abdisalan Mohamed Noor

Description : Japanese Encephalitis (JE) is a vector-borne disease of major importance in Asia. Recent increases in cases have spawned the development of more stringent JE surveillance. Due to the difficulty of making a clinical diagnosis, increased tracking of common symptoms associated with JE—generally classified as the umbrella term, acute encephalitis syndrome (AES) has been developed in many countries. In Nepal, there is some debate as to what AES cases are, and ho...

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Plos One : Genetic Diversity, Linkage Disequilibrium and Selection...

By: Christine A. Kozak

Description : To investigate population structure, linkage disequilibrium (LD) pattern and selection signature at the genome level in Chinese and Western pigs, we genotyped 304 unrelated animals from 18 diverse populations using porcine 60 K SNP chips. We confirmed the divergent evolution between Chinese and Western pigs and showed distinct topological structures of the tested populations. We acquired the evidence for the introgression of Western pigs into two Chinese pi...

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Plos One : Slipping Through the Cracks ; Rubber Plantation is Unsu...

By: Benedikt R. Schmidt

Description : Conversion of tropical forests into agriculture may present a serious risk to amphibian diversity if amphibians are not able to use agricultural areas as habitat. Recently, in Xishuangbanna Prefecture, Yunnan Province – a hotspot of frog diversity within China – two-thirds of the native tropical rainforests have been converted into rubber plantation agriculture. We conducted surveys and experiments to quantify habitat use for breeding and non-breeding life ...

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Plos One : Increased Baseline Proinflammatory Cytokine Production ...

By: Stephen J. Polyak

Description : RVR was associated with increased baseline proinflammatory cytokine production by TLR-4 stimulated monocytes and by activated lymphocytes. In null-responders and in patients who did not achieve SVR both TLR-4 sensing function and proinflammatory cytokine production were impaired, suggesting that modulation of TLR activity and controlled induction of inflammatory cytokine production may provide further therapeutic strategy for CHC patients nonresponding to P/R treatment.

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Plos One : Kml001 Displays Vascular Disrupting Properties and Irin...

By: Irina V. Lebedeva

Description : Heimesaat

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Plos One : Demographic Variation Between Colour Patterns in a Temp...

By: Athanassios C. Tsikliras

Description : Fish populations are often treated as homogeneous units in typical fishery management, thereby tacitly ignoring potential intraspecific variation which can lead to imprecise management rules. However, intraspecific variation in life-history traits is widespread and related to a variety of factors. We investigated the comparative age-based demography of the two main colour patterns of Labrus bergylta (plain and spotted, which coexist in sympatry), a commerci...

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Plos One : Identification of Highly Selective and Potent Histone D...

By: Manfred Jung

Description : To find histone deacetylase 3 (HDAC3)-selective inhibitors, a series of 504 candidates was assembled using ‘‘click chemistry’’, by reacting nine alkynes bearing a zinc-binding group with 56 azide building blocks in the presence of Cu(I) catalyst. Screening of the 504-member triazole library against HDAC3 and other HDAC isozymes led to the identification of potent and selective HDAC3 inhibitors T247 and T326. These compounds showed potent HDAC3 inhibition wi...

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Plos One : Variation in Trans-39-hydroxycotinine Glucuronidation D...

By: Richard H. Barton

Description : Variation in 3HC glucuronidation activity, including these caused by UGT2B17 gene deletions, did not significantly alter NMR and is therefore unlikely to affect the clinical utility of NMR in smoking behavior and cessation studies. This study demonstrates that NMR is not altered by differences in the rate of 3HC glucuronidation, providing further support that NMR is a reliable indicator of CYP2A6 mediated nicotine metabolism.

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Plos One : Use of a Dual Reporter Plasmid to Demonstrate Bactofect...

By: Bruce W. Banfield

Description : A reporter plasmid pSRG has been developed which expresses red fluorescent protein (RFP) from a constitutive prokaryotic promoter within Pasteurella multocida B:2 and green fluorescent protein (GFP) from a constitutive eukaryotic promoter within mammalian cells. This construct has been used to determine the location and viability of the bacteria when moving from the extracellular environment into the intracellular compartment of mammalian cells. Invasion as...

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Plos One : Malaria Infected Mosquitoes Express Enhanced Attraction...

By: George Dimopoulos

Description : There is much evidence that some pathogens manipulate the behaviour of their mosquito hosts to enhance pathogen transmission. However, it is unknown whether this phenomenon exists in the interaction of Anopheles gambiae sensu stricto with the malaria parasite, Plasmodium falciparum - one of the most important interactions in the context of humanity, with malaria causing over 200 million human cases and over 770 thousand deaths each year. Here we demonstrate...

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Plos One : High Proportion of Male Faeces in Jaguar Populations, V...

By: Matt Hayward

Description : Faeces provide relevant biological information which includes, with the application of genetic techniques, the sex and identity of individuals that defecated, thus providing potentially useful data on the behaviour and ecology of individuals, as well as the dynamics and structure of populations. This paper presents estimates of the sex ratio of different felid species (jaguar, Panthera onca: puma, Puma concolor: and ocelot/margay, Leopardus pardalis/Leopard...

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Plos One : Trajectories of Quality of Life Among Chinese Patients ...

By: James Coyne

Description : Objective : This secondary longitudinal analysis describes distinct quality of life trajectories during eight months of radiation therapy (RT) among patients with nasopharyngeal cancer (NPC) and examines factors differentiating these trajectories. Methods : 253 Chinese patients with NPC scheduled for RT were assessed at pre-treatment, and 4 months and 8 months later on QoL (Chinese version of the FACT-G), optimism, pain, eating function, and patient satisfa...

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Plos One : the Importance of Group-wise Registration in Tract Base...

By: Kewei Chen

Description : Tract-based spatial statistics (TBSS) is a popular method for the analysis of diffusion tensor imaging data. TBSS focuses on differences in white matter voxels with high fractional anisotropy (FA), representing the major fibre tracts, through registering all subjects to a common reference and the creation of a FA skeleton. This work considers the effect of choice of reference in the TBSS pipeline, which can be a standard template, an individual subject from...

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Plos One : Barley Hvhma1 is a Heavy Metal Pump Involved in Mobiliz...

By: Hendrik W. Van Veen

Description : Heavy metal transporters belonging to the P1B-ATPase subfamily of P-type ATPases are key players in cellular heavy metal homeostasis. Heavy metal transporters belonging to the P1B-ATPase subfamily of P-type ATPases are key players in cellular heavy metal homeostasis. In this study we investigated the properties of HvHMA1, which is a barley orthologue of Arabidopsis thaliana AtHMA1 localized to the chloroplast envelope. HvHMA1 was localized to the periphery ...

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Plos One : Milano Summer Particulate Matter Pm10 Triggers Lung Inf...

By: Michelle L. Block

Description : Recent studies have suggested a link between particulate matter (PM) exposure and increased mortality and morbidity associated with pulmonary and cardiovascular diseases: accumulating evidences point to a new role for air pollution in CNS diseases. The purpose of our study is to investigate PM10sum effects on lungs and extra pulmonary tissues. Milano PM10sum has been intratracheally instilled into BALB/c mice. Broncho Alveolar Lavage fluid, lung parenchyma,...

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Plos One : a Genome-wide Screen of Creb Occupancy Identifies the R...

By: Michal Hetman

Description : Neurotrophin-regulated gene expression is believed to play a key role in long-term changes in synaptic structure and the formation of dendritic spines. Brain-derived neurotrophic factor (BDNF) has been shown to induce increases in dendritic spine formation, and this process is thought to function in part by stimulating CREB-dependent transcriptional changes. To identify CREB-regulated genes linked to BDNF-induced synaptogenesis, we profiled transcriptional ...

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Plos One : a Comparison of the Contractile Properties of Myometriu...

By: Wei Yan

Description : We have found significant differences in contractile properties between myometrium from singleton and twin pregnancies and that increasing uterine stretch can alter the contractile properties of myometrium. We discuss the implication of these findings to preterm delivery and future studies

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Plos One : Effect of Health Expenses on Household Capabilities and...

By: Joan Muela Ribera

Description : The effects of health expenses on consumption patterns might well create or exacerbate poverty and poor health, particularly for low income households. We define health expenditures as catastrophic by their reductions of basic capabilities. Health policy should reform the OOP system that causes this economic and social burden.

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Plos One : Structural and Functional Analysis of the N-terminal Do...

By: Indranil Biswas

Description : The commensal Streptococcus gordonii expresses numerous surface adhesins with which it interacts with other microorganisms, host cells and salivary proteins to initiate dental plaque formation. However, this Gram-positive bacterium can also spread to non-oral sites such as the heart valves and cause infective endocarditis. One of its surface adhesins, Sgo0707, is a large protein composed of a non-repetitive N-terminal region followed by several C-terminal r...

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