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Plos One : Meta-analysis of the Relationship Between Common Type 2...

By: Sudha Chaturvedi

Description : This meta-analysis found 8 genetic variants associated with GDM. The relative contribution and relevance of the identified genes in the pathogenesis of GDM should be the focus of future studies.

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Plos One : Saikosaponin a Mediates the Anticonvulsant Properties i...

By: Luis Eduardo M. Quintas

Description : Epilepsy is one of the most common neurological disorders, yet its treatment remains unsatisfactory. Saikosaponin a (SSa), a triterpene saponin derived from Bupleurum chinensis DC., has been demonstrated to have significant antiepileptic activity in a variety of epilepsy models in vivo. However, the electrophysiological activities and mechanisms of the antiepileptic properties of SSa remain unclear. In this study, whole-cell current-clamp recordings were us...

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Plos One : Effects of Landscape-scale Environmental Variation on G...

By: Mark S. Boyce

Description : Effective long-term wildlife conservation planning for a species must be guided by information about population vital rates at multiple scales. Greater sage-grouse (Centrocercus urophasianus) populations declined substantially during the twentieth century, largely as a result of habitat loss and fragmentation. In addition to the importance of conserving large tracts of suitable habitat, successful conservation of this species will require detailed informati...

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Plos One : Cost-effectiveness of Pre-exposure Prophylaxis Prep in ...

By: S. Emma McBryde

Description : Even in settings with low test rates and treatment retention, the use of PrEP can still be a useful strategy in averting infections. Our model has shown that PrEP is a cost-effective strategy for reducing HIV incidence, even when adherence is suboptimal and prioritization is imperfect.

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Plos One : Comparative Analysis of the Transcriptome in Tissues Se...

By: Gen Hua Yue

Description : The triangle sail mussel Hyriopsis cumingii (Lea) is the most important mussel species used for commercial freshwater pearl production in China. Mussel color is an important indicator of pearl quality. To identify genes involved in the nacre coloring, we conducted RNA-seq and obtained 541,268 sequences (298 bp average size) and 440,034 sequences (293 bp average size) in secreting purple and white nacre libraries (P- and W-libraries), respectively. The 981,3...

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Plos One : Molecular Diagnosis of Usher Syndrome ; Application of ...

By: Osman El-maarri

Description : Usher syndrome (USH) is a clinically and genetically heterogeneous disorder characterized by visual and hearing impairments. Clinically, it is subdivided into three subclasses with nine genes identified so far. In the present study, we investigated whether the currently available Next Generation Sequencing (NGS) technologies are already suitable for molecular diagnostics of USH. We analyzed a total of 12 patients, most of which were negative for previously ...

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Plos One : Chronic Intermittent Fasting Improves Cognitive Functio...

By: Zhongcong Xie

Description : Obesity is a major health issue. Obesity started from teenagers has become a major health concern in recent years. Intermittent fasting increases the life span. However, it is not known whether obesity and intermittent fasting affect brain functions and structures before brain aging. Here, we subjected 7-week old CD-1 wild type male mice to intermittent (alternate-day) fasting or high fat diet (45% caloric supplied by fat) for 11 months. Mice on intermitten...

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Plos One : Influence of Non-alcoholic Fatty Liver Disease on Auton...

By: Manlio Vinciguerra

Description : NAFLD is associated with decreased Ln SDNN and increased 0 V percentage. The former association was independent of conventional cardiovascular risk factors and serum biomarkers (insulin resistance and leptin). Further risk stratification of autonomic dysfunction with falls or cardiovascular diseases by these HRV parameters is required in patients with NAFLD.

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Plos One : the Novel Ubiquitin Ligase Complex, Scffbxw4, Interacts...

By: Deanna M. Koepp

Description : Identification of novel proteins that can potentially contribute to carcinogenesis is a requisite venture. Herein, we report the first biochemical characterization of the novel F-box and WD40 containing protein, FBXW4. We have identified interacting protein partners and demonstrated that FBXW4 is part of a ubiquitin ligase complex. Furthermore, the Fbxw4 locus is a common site of proviral insertion in a variety of retroviral insertional mutagenesis murine c...

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Plos One : Insulin-like Growth Factor 1 Receptor Igf1R Expression ...

By: Rodrigo Alexandre Panepucci

Description : IGF1R-alpha protein overexpression may serve as an independent predictor of relapse and survival in operable laryngeal cancer. Prospective evaluation of the IGF1R-alpha prognostic utility is warranted.

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Plos One : Childhood Hyperactivity, Physical Aggression and Crimin...

By: Monica Da Silva Nunes

Description : Although the contribution of childhood hyperactivity to criminality may be detected in large samples using multi-informant longitudinal designs, our results show that it is not a strong predictor of later criminality. Crime prevention should instead target children with the highest levels of childhood physical aggression and family adversity.

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Plos One : Reduced Variability of Ongoing and Evoked Cortical Acti...

By: Olaf Sporns

Description : Sensory responses of the brain are known to be highly variable, but the origin and functional relevance of this variability have long remained enigmatic. Using the variable foreperiod of a visual discrimination task to assess variability in the primate cerebral cortex, we report that visual evoked response variability is not only tied to variability in ongoing cortical activity, but also predicts mean response time. We used cortical local field potentials, ...

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Plos One : Nuclear Genetic Diversity in Human Lice Pediculus Human...

By: Colin Dale

Description : Understanding the evolution of parasites is important to both basic and applied evolutionary biology. Knowledge of the genetic structure of parasite populations is critical for our ability to predict how an infection can spread through a host population and for the design of effective control methods. However, very little is known about the genetic structure of most human parasites, including the human louse (Pediculus humanus). This species is composed of ...

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Plos One : Multilamellar Structures and Filament Bundles Are Found...

By: Stefan F.T. Weiss

Description : Inside cells, viruses build specialized compartments for replication and morphogenesis. We observed that virus release associates with specific structures found on the surface of mammalian cells. Cultured adherent cells were infected with a bunyavirus and processed for oriented sectioning and transmission electron microscopy. Imaging of cell basal regions showed sophisticated multilamellar structures (MLS) and extracellular filament bundles with attached vi...

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Plos One : Sensitivity of Temperate Desert Steppe Carbon Exchange ...

By: Ben Bond-lamberty

Description : Arid grassland ecosystems have significant interannual variation in carbon exchange: however, it is unclear how environmental factors influence carbon exchange in different hydrological years. In this study, the eddy covariance technique was used to investigate the seasonal and interannual variability of CO2 flux over a temperate desert steppe in Inner Mongolia, China from 2008 to 2010. The amounts and times of precipitation varied significantly throughout ...

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Plos One : Dioxin Tcdd Induces Epigenetic Transgenerational Inheri...

By: Toshi Shioda

Description : Environmental compounds can promote epigenetic transgenerational inheritance of adult-onset disease in subsequent generations following ancestral exposure during fetal gonadal sex determination. The current study examined the ability of dioxin (2,3,7,8-tetrachlorodibenzo[p]dioxin, TCDD) to promote epigenetic transgenerational inheritance of disease and DNA methylation epimutations in sperm. Gestating F0 generation females were exposed to dioxin during fetal...

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Plos One : Community-based Management ; Under What Conditions Do S...

By: Kamal Bawa

Description : Community-based management (CBM) has been implemented in socio-ecological systems (SES) worldwide. CBM has also been the prevailing policy in Sa´mi pastoral SES in Norway, but the outcomes tend to vary extensively among resource groups (‘‘siidas’’). We asked why do some siidas self-organize to manage common pool resources sustainably and others do not? To answer this question we used a mixed methods approach. First, in the statistical analyses we analyzed t...

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Plos One : Therapeutic Effect of Human Ips-cell-derived Myeloid Ce...

By: Joseph Najbauer

Description : We recently developed a method to generate myeloid cells with proliferation capacity from human iPS cells. iPS-ML (iPScell- derived myeloid/macrophage line), generated by introducing proliferation and anti-senescence factors into iPS-cellderived myeloid cells, grew continuously in an M-CSF-dependent manner. A large number of cells exhibiting macrophagelike properties can be readily obtained by using this technology. In the current study, we evaluated the po...

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Plos One : Nucleolin Participates in Dna Double-strand Break- Indu...

By: Thomas G. Hofmann

Description : H2AX is an important factor for chromatin remodeling to facilitate accumulation of DNA damage-related proteins at DNA double-strand break (DSB) sites. In order to further understand the role of H2AX in the DNA damage response (DDR), we attempted to identify H2AX-interacting proteins by proteomics analysis. As a result, we identified nucleolin as one of candidates. Here, we show a novel role of a major nucleolar protein, nucleolin, in DDR. Nucleolin interact...

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Plos One : Sensory-motor Interactions for Vocal Pitch Monitoring i...

By: S. Michael Beauchamp

Description : The neural mechanisms underlying processing of auditory feedback during self-vocalization are poorly understood. One technique used to study the role of auditory feedback involves shifting the pitch of the feedback that a speaker receives, known as pitch-shifted feedback. We utilized a pitch shift self-vocalization and playback paradigm to investigate the underlying neural mechanisms of audio-vocal interaction. High-resolution electrocorticography (ECoG) si...

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