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Carboxypeptidase B

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Title: Carboxypeptidase B  
Author: World Heritage Encyclopedia
Language: English
Subject: Carboxypeptidase A, Proteases, Enkephalinase, Carboxypeptidase A6, Glutamate carboxypeptidase II
Collection: Ec 3.4.17, Metabolism
Publisher: World Heritage Encyclopedia

Carboxypeptidase B

carboxypeptidase B1 (tissue)
Symbol CPB1
Entrez 1360
HUGO 2299
OMIM 114852
RefSeq NM_001871
UniProt P15086
Other data
EC number
Locus Chr. 3 q24
carboxypeptidase B2 (plasma)
Symbol CPB2
Entrez 1361
HUGO 2300
OMIM 603101
RefSeq NM_016413
UniProt Q96IY4
Other data
Locus Chr. 13 q14.11
carboxypeptidase B
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

Carboxypeptidase B (EC, protaminase, pancreatic carboxypeptidase B, tissue carboxypeptidase B, peptidyl-L-lysine [L-arginine]hydrolase) is a carboxypeptidase that preferentially acts upon basic amino acids, such as arginine and lysine.[1][2][3][4] This serum enzyme is also responsible for rapidly metabolizing the C5a protein into C5a des-Arg, with one less amino acid.


  1. ^ Folk, J.E. (1970). "Carboxypeptidase B (porcine pancreas)". Methods Enzymol. 19: 504–508.  
  2. ^ Brodrick, J.W., Geokas, M.C. and Largman, C. (1976). "Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion". Biochim. Biophys. Acta 452: 468–481.  
  3. ^ Butterworth, J. and Duncan, J.J. (1979). "Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis". Clin. Chim. Acta 97: 39–43.  
  4. ^ Wallace, E.F., Evans, C.J., Jurik, S.M., Mefford, I.N. and Barchas, J.D. (1982). "Carboxypeptidase B activity from adrenal medulla. Is it involved in the processing of proenkephalin?". Life Sci. 31: 1793–1796.  

External links

  • The MEROPS online database for peptidases and their inhibitors: M14.003
  • Carboxypeptidase B at the US National Library of Medicine Medical Subject Headings (MeSH)
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