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Physalaemin

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Title: Physalaemin  
Author: World Heritage Encyclopedia
Language: English
Subject: List of MeSH codes (D12.644), List of MeSH codes (D23), Pyrrolidones, Neoendorphin, Galanin-like peptide
Collection: Neuropeptides, Phenols, Pyrrolidones
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Physalaemin

Physalaemin
Identifiers
 Y
ChEMBL  N
MeSH
PubChem
Properties
C58H84N14O16S
Molar mass 1265.44 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N  (: Y/N?)

Physalaemin is a tachykinin peptide obtained from the Physalaemus frog, closely related to substance P. Its structure was first elucidated in 1964.[1][2]

Like all tachykinins, physalaemin is a sialagogue (increases salivation) and a potent vasodilator with hypotensive effects.[3]

References

  1. ^ Erspaemer V, Anastasi A, Bertaccini G, Cei JM (1964). "Structure and pharmacological actions of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus". Experientia 20 (9): 489–90.  
  2. ^ Anastasi A, Erspamer V, Cei JM (1964). "Isolation and amino acid sequence of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus". Arch Biochem Biophys 108 (2): 341–8.  
  3. ^ Severini C, Improta G, Falconieri-Erspamer G, Salvadori S, Erspamer V (2002). "The tachykinin peptide family". Pharmacol Rev 54 (2): 285–322.  
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