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Title: Blastema  
Author: World Heritage Encyclopedia
Language: English
Subject: Blastema.jpg, Supernumerary kidney, Metanephrogenic blastema, Developmental biology, Wilms' tumor
Collection: Developmental Biology
Publisher: World Heritage Encyclopedia


Blastema cells surrounded by transparent cystic spaces.

A blastema is a mass of bone.[2]

Some amphibians and certain species of fish can produce blastemas as adults.[3] For example, retina and intestine.[4] Most animals, however, cannot produce blastemas.

Limb Regeneration

When the limb of the salamander is cut off, a layer of epidermis covers the surface of the amputation site. In the first few days after the injury, this wounded epidermis transforms into a layer of signaling cells called the Apical Epithelial Cap (AEC), which has a vital role in regeneration. In the meantime, fibroblasts from the connective tissue migrate across the amputation surface to meet at the center of the wound. These fibroblasts multiply to form a blastema, the progenitor for a new limb.[5]


  1. ^ Krag, Martin; Knapp, Dunja; Nacu, Eugen; Khattak, Shahryar; Maden4, Malcolm; Epperlein, Hans Henning; Tanaka, Elly M. (July 2009). "Cells keep a memory of their tissue origin during axolotl limb regeneration". Nature 460 (7251): 60–65.  
  2. ^ Tanaka, Elly (July 19, 2011). "The cellular basis for animal regeneration". Developmental Cell 21 (1): 172–185. 
  3. ^ Godwin, James (September 2014). "The promise of perfect adult tissue repair and regeneration in mammals: Learning from regenerative amphibians and fish". BioEssays 36 (9): 861–871. 
  4. ^ Wade, Nicholas (April 11, 2006). "Regrow Your Own". New York Times. Retrieved February 2010. 
  5. ^ Christensen RN, Tassava RA (February 2000). <216::AID-DVDY8>3.0.CO;2-8 "Apical epithelial cap morphology and fibronectin gene expression in regenerating axolotl limbs".  

Further reading

  • Becker, Robert O.; Gary Selden (1998).  

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