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Cathepsin A

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Title: Cathepsin A  
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Subject: Lysosomal storage disease, Cathepsin, Chromosome 20 (human), Carboxypeptidase C
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Cathepsin A

Cathepsin A
PDB rendering based on 1ivy.
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

Cathepsin A is an enzyme that is classified both as a cathepsin and a carboxypeptidase. In humans, it is encoded by the CTSA gene.[1]


This gene encodes a glycoprotein that associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high-molecular-weight multimers. The formation of this complex provides a protective role for stability and activity. It is protective for β-galactosidase and neuraminidase.[2]

Clinical significance

Deficiencies in this gene are linked to multiple forms of galactosialidosis.[1]


Cathepsin A has been shown to interact with NEU1.[3]


Further reading

External links

  • Medical Subject Headings (MeSH)
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