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Are Human Studies Possible Some Thoughts on the Mutation Component and Population Monitoring

By Denniston, Carter

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Book Id: WPLBN0000016464
Format Type: PDF eBook
File Size: 0.3 MB
Reproduction Date: 2005

Title: Are Human Studies Possible Some Thoughts on the Mutation Component and Population Monitoring  
Author: Denniston, Carter
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Denniston, C. (n.d.). Are Human Studies Possible Some Thoughts on the Mutation Component and Population Monitoring. Retrieved from

Government Reference Publication

Excerpt: Committees attempting to assess the effect of an increased mutation rate on the human population always face the difficulty posed by what BEIR 111 (I) called irregularly inherited disorders. They state: The population survey of British Columbia reported that at least 9% of live horn humans will he seriously handicapped at some time during their life times by genetic disorders of complex etiology, manifested as congenital malformations, anomalies expressed later, or constitutional and degenerative diseases. This, the largest category of genetic disorder. . . we refer to as irregularly inherited disorders. They go on: An estimate of the number of induced irregularly inherited disorders present at equilibrium must take into account the proportion of the incidence of these disorders that would vary directly with the mutation rate, a quantity that BEIR I called the mutational component. More precisely, if the equilihrium incidence, I, of a disorder is a linear function of the mutation rate, rn, i.e., I = a + brn, then we define the mutational component to be MC = brn/(o + bm), in which case the relative increase of the disorder incidence after an increase in the mutation rate from m to say, rn(1 + kl is (l - nil = (MClk. Each disorder may have its own mutational component, and a class of disorders, such as irregularly inherited disorders, its average mutational component.?


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