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The National Center for Toxicogenomics : Using New Technologies to Inform Mechanistic Toxicology

By Department of Health and Human Services

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Book Id: WPLBN0000023779
Format Type: PDF eBook
File Size: 0.6 MB
Reproduction Date: 2005
Full Text

Title: The National Center for Toxicogenomics : Using New Technologies to Inform Mechanistic Toxicology  
Author: Department of Health and Human Services
Volume:
Language: English
Subject: Health., Medical research, Medical reports
Collections: Medical Library Collection
Historic
Publication Date:
Publisher: Centers for Disease Control and Prevention

Excerpt
The science of toxicology has evolved from the empirical codification of dose-related effects to studies directed toward understanding the mechanisms by which individual agents cause their effects in humans. Due to technical limitations, this evolution has been relatively slow, being accomplished one chemical or one effect at a time. To prospectively use the understanding gained on the mode of action of a single chemical, it is also necessary to know about structurally and functionally related chemicals and their time- and dose-dependent biological effects. In addition to chemicals and drugs, there are a plethora of environmental factors and stressors, such as ultraviolet and ionizing radiation, biological agents, and dietary and lifestyle components, that can contribute to the development of disease. The effects of all of these agents must be characterized to a progressively greater depth for us to understand the biochemical and genetic complexity of the cells in which adverse effects are manifested. In this view, toxicology will progressively develop from predominantly individual chemical studies into a knowledge-based science in which experimental data are compiled and computational and informatics tools will play a significant role in deriving a new understanding of toxicant-related disease (1).

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