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Differentiating Toxicities of Conazole Fungicides through Metabonomic Analyses of Multiple Tissues

By Environmental Protection Agency

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Book Id: WPLBN0000027488
Format Type: PDF eBook
File Size: 0.1 MB
Reproduction Date: 2007
Full Text

Title: Differentiating Toxicities of Conazole Fungicides through Metabonomic Analyses of Multiple Tissues  
Author: Environmental Protection Agency
Language: English
Subject: Ecology, Natural resource issues, Environemtal protection
Collections: Environmental Awareness Library Collection
Publication Date:
Publisher: United States Environmental Protection Agency

Excerpt: The conazole fungicides represent a large group of compounds widely used agriculturally for the protection of crop plants (Hutson, 1998) and pharmaceutically in the treatment of topical and systemic infections (Sheehan, 1999). In 1999, the latest period for which agricultural usage estimates are available, 79 and 556 million pounds of fungicide active ingredient were used in the U.S. and world markets, respectively (Donaldson, 2002), creating concern over the impact these compounds may have through environmental exposure to humans and other organisms. In an attempt to better understand the toxicities of these compounds, an NMR (Nuclear Magnetic Resonance)-based metabonomics approach was used to determine differences in the toxicities of two conazole fungicides (myclobutanil and triadimefon) by analyses of metabolite changes occurring in blood serum, liver tissue, and testicular tissue of control and exposed rats. Metabonomics is the quantitative measurement of a broad spectrum of metabolic responses of living systems in response to disease onset or genetic modification. By monitoring changes in cellular metabolites in response to the introduction of a toxicant, the biochemical pathways affected can be determined and the specific toxic response characterized on a molecular level. Furthermore, metabonomic data can be used in conjunction with genomic and proteomic data to more fully characterize environmental effects. Through the combined efforts of the U.S. Environmental Protection Agency (U.S. EPA), the Procter and Gamble Company, and the Imperial College (London, England), distinct metabolite profiles produced by exposure to conazole fungicides were identified. These metabonomic profiles identify potential biological pathways responding to the exposures.


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