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Ddt and Its Metabolites Alter Gene Expression in Human Uterine Cell Lines through Estrogen Receptor-Independent Mechanisms

By Frigo, Daniel E.

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Book Id: WPLBN0000048304
Format Type: PDF eBook
File Size: 0.6 MB
Reproduction Date: 2005

Title: Ddt and Its Metabolites Alter Gene Expression in Human Uterine Cell Lines through Estrogen Receptor-Independent Mechanisms  
Author: Frigo, Daniel E.
Volume:
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
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Publisher: United Nations- Office for Disarmament Affairs (Unoda)

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Frigo, D. E. (n.d.). Ddt and Its Metabolites Alter Gene Expression in Human Uterine Cell Lines through Estrogen Receptor-Independent Mechanisms. Retrieved from http://www.ebooklibrary.org/


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Government Reference Publication

Excerpt
Excerpt: Extracellular signals such as growth factors, hormones, and environmental compounds elicit an array of effects on a cell that include proliferation, differentiation, stress, and death (1?3). In many cases, external stimuli signal a cell, resulting in the activation or inhibition of transcription factors such as activator protein-1 (AP-1) and nuclear factor ?B (NF?B), which form complexes and regulate gene expression (4,5). The resultant change in gene expression leads to an overall effect on the cell, dictating its final interpretation of the external cue. Determining what signals target transcription factors and how they do so is key to understanding the specificity of gene expression and resultant biological responses.

 

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