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Interactions of Chrysotile Asbestos with Erythrocyte Embranes

By Hill, Lila H.

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Book Id: WPLBN0000077648
Format Type: PDF eBook
File Size: 2.6 MB
Reproduction Date: 2005

Title: Interactions of Chrysotile Asbestos with Erythrocyte Embranes  
Author: Hill, Lila H.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Hill, L. H. (n.d.). Interactions of Chrysotile Asbestos with Erythrocyte Embranes. Retrieved from

Government Reference Publication

Excerpt: Chrysotile is the most toxic asbestiform mineral 0). This asbestos type causes fibrotic and neoplastic lung disease consequent to inhalation by animals (2) and man (9). The mechanisms through which chrys* t i e asbestos exerts its toxic effects have been speculated upon U,4,5). One reasonable hypothesis is that positively charged magnesium ions on the surface of the asbestos fibers bind to negatively charged sialoglycoproteins on cell membranes (I). This has been tested in erythrocyte systems where hemolysis is measured (6) and in cultured cells studied biochemically (71. We have addressed this bypothesis further by studying the distribution of erythrocyte membrane glycoproteins before and after treatment with chrysotile asbestos. The significance of changes in cell surface glycoprotein distribution is assessed by correlative studies of intracellular Na to K ratios.


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