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Binding of Benzidine, N=Acetylbenzidine, N, N-Diacetylbenzidine and Direct Blue 6 to Rat Liver Dna

By Kennelly, J. C.

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Book Id: WPLBN0000102629
Format Type: PDF eBook
File Size: 0.3 MB
Reproduction Date: 2005

Title: Binding of Benzidine, N=Acetylbenzidine, N, N-Diacetylbenzidine and Direct Blue 6 to Rat Liver Dna  
Author: Kennelly, J. C.
Volume:
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Historic
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)

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Kennelly, J. C. (n.d.). Binding of Benzidine, N=Acetylbenzidine, N, N-Diacetylbenzidine and Direct Blue 6 to Rat Liver Dna. Retrieved from http://www.ebooklibrary.org/


Description
Government Reference Publication

Excerpt
Excerpt: Benzidine (BZ) has been shown to induce tumors at various sites in laboratory animals (1, 2). The major target organ in the rat and mouse is the liver, whereas tumors of the bladder are observed in dogs. BZ is also known to be responsible for the induction of bladder cancer in humans occupationally exposed to this compound 4). Morton et al. (5) have shown in vitro that BZ can be sequentially acetylated to N-acetylbenzidine (ABZ) and N,N- diacetylbenzidine (DABZ). This latter species was then demonstrated to be a substrate for hepatic NO-acyltransferase (5, 6) and hepatic sulfotransferase (n and to form reactive intermediates that would covalently bind to nucleophiles. More recently, Morton and ceworkers (8)r eported that BZ and N-hydroxy-DABZ were more carcinogenic than DABZ in rats; however, the metabolic activation pathways responsible for tumor induction were not lnridated.

 

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