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Interspecies Variation in Myocardial Physiology : The Anomalous Rat

By Langer, Glenn A.

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Book Id: WPLBN0000117959
Format Type: PDF eBook
File Size: 0.3 MB
Reproduction Date: 2005

Title: Interspecies Variation in Myocardial Physiology : The Anomalous Rat  
Author: Langer, Glenn A.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Langer, G. A. (n.d.). Interspecies Variation in Myocardial Physiology : The Anomalous Rat. Retrieved from

Government Reference Publication

Excerpt: In many biological investigations it is the mutant organism or the anomalous species which frequently provides additional insights into basic mechanisms of function. Definition of the basis for an anomaly may further define the normal condition. In the area of mammalian myocardial physiology the rat has provided just such an anomalous condition. The rat heart demonstrates anomalies with respect to its action potential (1. 2), forcefrequency response (1-3), ionic exchange parameters (2. 4 4) and response to digitalis glycosides (2. 7, 8). Investigation of these characteristics has provided further insight into fundamental properties of myocardial function not only in the rat but in other mammalian species. I will first review the anomalies and then attempt to correlate them in such a manner as to indicate how the information has provided further definition of a model for control of myocardial force development.


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