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Metabolic Activationldeactivation Reactions during Perinatal Development

By Lucier, George W.

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Book Id: WPLBN0000130787
Format Type: PDF eBook
File Size: 0.6 MB
Reproduction Date: 2005

Title: Metabolic Activationldeactivation Reactions during Perinatal Development  
Author: Lucier, George W.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Lucier, G. W. (n.d.). Metabolic Activationldeactivation Reactions during Perinatal Development. Retrieved from

Government Reference Publication

Excerpt: The role of metabolism in xenobiotic pharmacokinetics and toxicity has received considerable attention over the last two decades. The concept of metabolic activation of chemicals to reactive intermediates is critical in attempts to characterize the sequence of molecular events eventually leading to environmental carcinogenesis, mutagenesis and teratogenesis. A theoretical scheme whereby chemicals might initiate carcinogenesis could begin by exposure to an inactive precursor. The precursor could be converted to a reactive intermediate, presumably by the hepatic or extrahepatic monooxygenase system catalyzed by cytochrome P-448 or P-450. Reactive intermediates are thought to be electrophilic (often epoxides), and they can bind covalently to nucleophilic nitrogen, oxygen, or sulfur atoms or cellular macromolecules (I). Damaged macromolecules can result from this interaction resulting in the initiation of carcinogenesis.


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