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Environmental Health Perspectives, Vol. 107, No. 11, November 1999 : A Yeast Screen System for Aromatase Inhibitors and Ligands for Androgen Receptor-Yeast Cells Transformed with Aromatase and Androgen Receptor

By Mak, Paul

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Book Id: WPLBN0000134750
Format Type: PDF eBook
File Size: 0.9 MB
Reproduction Date: 2005

Title: Environmental Health Perspectives, Vol. 107, No. 11, November 1999 : A Yeast Screen System for Aromatase Inhibitors and Ligands for Androgen Receptor-Yeast Cells Transformed with Aromatase and Androgen Receptor  
Author: Mak, Paul
Volume:
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Historic
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)

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Mak, P. (n.d.). Environmental Health Perspectives, Vol. 107, No. 11, November 1999 : A Yeast Screen System for Aromatase Inhibitors and Ligands for Androgen Receptor-Yeast Cells Transformed with Aromatase and Androgen Receptor. Retrieved from http://www.ebooklibrary.org/


Description
Government Reference Publication

Excerpt
Excerpt: The conversion of androgens to estrogens is catalyzed by the enzyme aromatase, which belongs to the cytochrome P450 superfamily. Aromatase plays an important role in the expression of secondary sexual characteristics, maintenance of pregnancy, and brain sex differentiation (1). Furthermore, the enzyme has received considerable attention in breast cancer development because high expression of the enzyme activity has been associated with a significant number of breast tumors (2?4). Thus, aromatase inhibitors are used as therapeutic agents for the treatment of estrogen-dependent breast cancer by inhibition of estrogen production in addition to antiestrogen treatment.

 

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