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Inhalation Toxicology of Isoprene in F344 Rats and B6C3F, Mice Following Two- Week Exposures

By Mehick, Ronald L.

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Book Id: WPLBN0000144999
Format Type: PDF eBook
File Size: 0.4 MB
Reproduction Date: 2005

Title: Inhalation Toxicology of Isoprene in F344 Rats and B6C3F, Mice Following Two- Week Exposures  
Author: Mehick, Ronald L.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Mehick, R. L. (n.d.). Inhalation Toxicology of Isoprene in F344 Rats and B6C3F, Mice Following Two- Week Exposures. Retrieved from

Government Reference Publication

Excerpt: Isoprene (2-methyl-1,3-butadiene; CAS No. 78-79-5) was selected for toxicologic evaluations because of its structural similarity to 1,3-hutadiene. The latter compound produced one of the most unusual responses in a long-term study by the National Toxicology Program (1,2): a high rate of early mortality due to fatal tumors in B6C3Fl mice exposed to 625 or 1250 ppm of 1,s-butadiene, seven primary sites of neoplastic development, and induction of uncommon tumors such as hemangiosarcoma of the heart. To investigate the influence of the 2-methyl substituent on the toxicologic profile of 1,3- butadiene, inhalation toxicology studies of isoprene were initiated. Isoprene differs physically from butadiene in that it is a liquid at room temperature (boiling point: 34C), whereas butadiene is a gas (boiling point: -4.4%). Isoprene is a high volatile material, having a vapor pressure of 493 mm Hg at 20?C (3). The annual production volume of isoprene in the United States is about 140 million pounds; this level is about 6% of the U.S. production volume of 1,3-butadiene (4). Isoprene is produced.


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