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Overview of Reproductive and Developmental Toxicity Studies of 1,3-Butadiene in Rodents

By Morrissey, Richard E.

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Book Id: WPLBN0000155787
Format Type: PDF eBook
File Size: 0.4 MB
Reproduction Date: 2005

Title: Overview of Reproductive and Developmental Toxicity Studies of 1,3-Butadiene in Rodents  
Author: Morrissey, Richard E.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Morrissey, R. E. (n.d.). Overview of Reproductive and Developmental Toxicity Studies of 1,3-Butadiene in Rodents. Retrieved from

Government Reference Publication

Excerpt: Two reports in the literature present information regarding the potential of 1,3-butadiene to cause reproductive or developmental toxicity in laboratory animals. In a reproductive study, male and female rats were exposed to 600,2300, or 6700 ppm of 1,3-butadiene for 8 months (5). A concentration-related depression of body weight was observed. Reproductive studies of male and female animals were performed at unstated times during these exposures, hut no data were given concerning the number of matings or of barren females. The number of litters from female rats in all exposed groups tended to be lower than in controls, although litter sizes were stated to slightly exceed the expected norm of six per litter. Limited breeding tests of the offspring of the 2300- and 6700-ppm exposure groups suggested that there was reduced fecundity, but it was not determined whether the deficit was associated with the males or the females. Although details were not provided, a small number of guinea pigs and rabbits was also used in each exposure group for reproductive studies. Animals of all groups evidently produced progeny, except for rabbits exposed to 600 and 2300 ppm. The basis for the authors conclusion that any apparent reduction in fertility was due to hereditary characteristics is not clear.


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