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Behavioral Teratology of Ethylene Glycol Monomethyl and Monoethyl Ethers

By Nelson, B. K.

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Book Id: WPLBN0000160213
Format Type: PDF eBook
File Size: 0.3 MB
Reproduction Date: 2005

Title: Behavioral Teratology of Ethylene Glycol Monomethyl and Monoethyl Ethers  
Author: Nelson, B. K.
Volume:
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Historic
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)

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Nelson, B. K. (n.d.). Behavioral Teratology of Ethylene Glycol Monomethyl and Monoethyl Ethers. Retrieved from http://www.ebooklibrary.org/


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Government Reference Publication

Excerpt
Excerpt: As teratological testing has evolved, there has been an increasing number of observations made on the offspring following maternal exposure to a variety of test agents. At tirst, offspring were probably just observed to see if they had the usual number of eyes and ears, and that they were located in the usual places. More sophistication was added when the pregnant animals were sacrificed and fetuses were examined closely for internal defects, whether by serially slicing them and looking for soft-tissue anomalies, or by staining their skeletons and looking for defects. More recently, investigators have recognized that functional assessment may detect deficits not observed by other techniques; proponents of this testing have hypothesized that functional assessment may be a more sensitive indicator of prenatal insult than are conventional techniques which rely on morphological changes. Hence, a variety of functional assessment techniques have been proposed for a number of organ systems: cardiovascular, immune, renal, respiratory and central nervous system (CNS). The last of these has received the greatest emphasis to date; its investigation is commonly referred to as behavioral teratology or developmental neurotoxicology.

 

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