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Age-Dependent Response of the Rat Testes to Di(2-Ethylhexyl) Phthalate

By Ploen, Leif

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Book Id: WPLBN0000185274
Format Type: PDF eBook
File Size: 1.1 MB
Reproduction Date: 2005

Title: Age-Dependent Response of the Rat Testes to Di(2-Ethylhexyl) Phthalate  
Author: Ploen, Leif
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Ploen, L. (n.d.). Age-Dependent Response of the Rat Testes to Di(2-Ethylhexyl) Phthalate. Retrieved from

Government Reference Publication

Excerpt: Di(2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer which has become widely distributed in the environment (1-3). Furthermore, blood and blood products may leach DEHP out of plasticized medical devices leading to inadvertent patient exposure during, e.g., hemodialysis and blood transfusions (4,5). As yet, exposure in humans is not known to be associated with any adverse effects. Administration of high oral doses of DEHP to rats have resulted in liver abnormalities and testicular damage (6,7). The effect on testes has been observed to vary with the age of the animal, younger rats being more sensitive than older ones (8). In this communication, possible mechanisms involved in this age dependency will be discussed.


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