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World Health Organization : Year 1987 ; The Special Programme for Research and Training in Tropical Diseases Immlep Swg (7) Issue 87.3: Report of the Seventh Meeting of the Scientific I Working Group (SWG) on the Immunology of Leprosy

By World Health Organization

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Book Id: WPLBN0000189204
Format Type: PDF eBook
File Size: 0.8 MB
Reproduction Date: 2005

Title: World Health Organization : Year 1987 ; The Special Programme for Research and Training in Tropical Diseases Immlep Swg (7) Issue 87.3: Report of the Seventh Meeting of the Scientific I Working Group (SWG) on the Immunology of Leprosy  
Author: World Health Organization
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
Publication Date:
Publisher: World Health Organization

Citation

APA MLA Chicago

Organization, W. H. (n.d.). World Health Organization : Year 1987 ; The Special Programme for Research and Training in Tropical Diseases Immlep Swg (7) Issue 87.3. Retrieved from http://www.ebooklibrary.org/


Description
Medical Reference Publication

Excerpt
1. SCIENTIFIC REPORT 1. 1 Tntroduction The seventh meeting of the Scientific Working Croup (SWG) on the Immunology of leprosy (LMMLEP) was held in Geneva, 9-11 June 1987, under tha auspices of the UNDP/WORLD BANK/WHO Special Programme for Research and Training in Tropical Diseases (TDR). Dr S.K. Noordeen opened the meeting with a brief review of the progress achieved by IMMLEP over the past five years. He described the setting up of field trials on the killed Mvcobacteriw hXE vaccine and progress in basic research on the development of second generation vaccines and immunodiagnostic tests, and announced the establishment of a Molecular Biology Subcommittee for the application of molecular biology to the immunology of leprosy. Dr Noordeen said that progress in the undcrstanding of i.mmunol.ogica? mechanisms in leprosy was most satisfactory but that relatively l it-tln pmEress has been made towards an understanding of the pathology of nerve dnrnsge. He $tressed the importance of relating research efforts to the clinical needs of leprosy control and management. The Chairman of: the meeting, Dr J. Ivanyi, pointed out ?hat thc main purpose of the meeting was to provide an update on recent progress in the immunol.ofiy of leprosy and to outline priorities for future research.

Table of Contents
CONTENTS 1 . SCIENTIFIC REPORT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.2 Structural and Biochemical Aspects of Mvcobacterium leorae . . . 2 1.3 Analysis of g . laorao Antigens Using Monoclonal Antibodies . . . 3 1.4 T-cell Recognition of Mycobacterial Antigens . . . . . . . . . . . . . . . . . 3 1.4.1 Identification of antigenic molecules . . . . . . . . . . . . . . . . . 3 1.4.2 T-cell epitope mapping . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.5 Mechanisms of Cellular Immunity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 1.5.1 Genetic restriction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 1.5.2 Suppressor T cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 1.5.3 Cytolytic T cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 1.5.e Macrophage activation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 1.5.5 Animal models . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 1.6 immunodiagnosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 1.7 Molecular Biology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 1.8 Immunopathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 1.9 IMMLEP fi . leorae Tissue Bank . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 1.10 Vaccine Trials . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 1.11 General Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 2 . FUTURE PRIORITIES AND RECOMMENDATIONS FOR RESEARCH . . . . . . . . . . . . . . . . 13 2.1 Biochemical Aspects and Tmmunodiagnosis . . . . . . . . . . . . . . . . . . . . . . 13 2.1.1 Proteins and peptides . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 2.1.2 Cell wall . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 2.1.3 LAM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1 4 2.1.b Immunodiagnosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 2.1.5 New antigens . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1L 2.2 Cellular Immune Rssponsivcness and Immunopathology . . . . . . . . . . . 14 2.2.1 Antigen characterization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 2.2.2 Immunodominance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 2.2.3 Immunoregulation and immunopathology . . . . . . . . . . . . . . . . . . 15 2.2.L Protective immunity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15

 

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