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Chemistry and Metabolism of Metals Relevant to Their Carcinogenicity

By United Nations

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Book Id: WPLBN0000189939
Format Type: PDF eBook
File Size: 0.5 MB
Reproduction Date: 2005

Title: Chemistry and Metabolism of Metals Relevant to Their Carcinogenicity  
Author: United Nations
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Nations, U. (n.d.). Chemistry and Metabolism of Metals Relevant to Their Carcinogenicity. Retrieved from

Government Reference Publication

Introduction: A variety of metals have been implicated in carcinogenesis in both animal and human studies. It is our purpose here to consider possible molecular mechanisms for the induction of cancer, not only by already identified metal carcinogens, but also by metal ions generally. The reason for this approach is that present knowledge of human metal carcinogens has come about haphazardly, as a result of effects produced in certain places where a population has been subjected to an unusual concentration of certain metals. Carcinogenic metals thus identified resemble in their chemistry and biochemistry other metals that have not been so characterized. Since no molecular mechanism of metal carcinogenesis is presently understood, our best efforts can be devoted to a consideration of those chemical interactions of metals that may lead to cancer. Such interactions can then be considered as bases for hypotheses for carcinogenesis, and are made available for further study.


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