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World Health Organization : Year 2001 ; Communicable Diseases and Emerging Infectious Diseases ; Department of Control, Prevention, And Eradication Gbui, No. 2001.4: Buruli Ulcer Diagnosis of Mycobacterium Ulcerans Disease

By Paul Johnson

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Book Id: WPLBN0000193250
Format Type: PDF eBook
File Size: 3.3 MB
Reproduction Date: 2005

Title: World Health Organization : Year 2001 ; Communicable Diseases and Emerging Infectious Diseases ; Department of Control, Prevention, And Eradication Gbui, No. 2001.4: Buruli Ulcer Diagnosis of Mycobacterium Ulcerans Disease  
Author: Paul Johnson
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
Publication Date:
Publisher: World Health Organization

Citation

APA MLA Chicago

Johnson, P. (n.d.). World Health Organization : Year 2001 ; Communicable Diseases and Emerging Infectious Diseases ; Department of Control, Prevention, And Eradication Gbui, No. 2001.4. Retrieved from http://www.ebooklibrary.org/


Description
Medical Reference Publication

Excerpt
Introduction In 1998, the World Health Organization (WHO) established the Global Buruli Ulcer Initiative (GBUI) in response to the growing spread and impact of Buruli ulcer, Mycobacterium ulcerans disease. The disease exists or has been suspected in at least 31 countries (Fig. 1). The primary objectives of the GBUI are: to raise awareness of the disease, to mobilize support for affected countries, to promote and to coordinate research activities and to coordinate the work of nongovernmental organizations (NGOs) and other partners. A summary of the achievements of the GBUI is presented in Annex 12. In 1897, Sir Albert Cook in Uganda described skin ulcers consistent with Buruli ulcer but he did not publish these cases in the medical literature. In 1948, MacCallum et al. published the first confirmed cases of the disease. These patients were in Australia. The disease was called Bairnsdale ulcer after the main town in the original endemic region. In southeastern Australia, the disease is still often referred to as Bairnsdale ulcer but, in parts of Africa, it is called “Buruli ulcer”, the name coming from a county in Uganda where large numbers of cases were reported in the 1950s.

Table of Contents
CONTENTS Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Illustrations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Chapter 1. Clinical diagnosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Chapter 2. Biosafety and record-keeping in the laboratory . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Chapter 3. Collection and transport of clinical specimens . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 Chapter 4. Secondary bacterial infection in M. ulcerans disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 Chapter 5. Microbiological methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 Chapter 6. Histopathological methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 Annex 1. Flow chart for the laboratory diagnosis of M. ulcerans disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48 Annex 2. Laboratory request form . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 Annex 3. Laboratory report form . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 Annex 4. Preparation of culture media . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 Annex 5. Microbiological staining techniques . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 54 Annex 6. Histopathological staining techniques . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59 Annex 7. Decontamination methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68 Annex 8. M. ulcerans culture with BACTEC 460 TB instrument . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71 Annex 9. Biochemical and culture tes

 

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