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Exposure to Pcbs and P, P-Dde and Human Sperm Chromatin Integrity

By Rignell-Hydbom, Anna

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Book Id: WPLBN0000198402
Format Type: PDF eBook
File Size: 0.3 MB
Reproduction Date: 2005

Title: Exposure to Pcbs and P, P-Dde and Human Sperm Chromatin Integrity  
Author: Rignell-Hydbom, Anna
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Hydbom, A. R. (n.d.). Exposure to Pcbs and P, P-Dde and Human Sperm Chromatin Integrity. Retrieved from

Government Reference Publication

Excerpt: Persistent organochlorine pollutants (POPs) such as polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (p,p-DDE), the major metabolite of dichlorodiphenyltrichloroethane (DDT), are stable lipophilic compounds widely found in the environment and in the general population. They can enter the food chain, and their negative impact on male reproduction is currently under active scrutiny. To explore the hypothesis that environmental exposure to these compounds is associated with altered sperm chromatin structure integrity in human sperm, we conducted a study of 176 Swedish fishermen (with low and high consumption of fatty fish, a very important exposure source of POPs). We determined serum levels of 2,2,4,4,5,5- hexachlorobiphenyl (CB-153) and p,p-DDE, and we used the sperm chromatin structure assay (SCSA) to assess sperm DNA/chromatin integrity. When CB-153 serum levels (individual dose range, 39?1,460 ng/g lipid) were categorized into equally sized quintiles, we found an association with the DNA fragmentation index (%DFI). A significantly lower %DFI was found in the lowest CB-153 quintile (< 113 ng/g lipid) compared with the other quintiles; there was a similar tendency, although not statistically significant, between %DFI and p,p-DDE. These results suggest that POP exposure may have a slight negative impact on human sperm chromatin integrity. Key words: DDE, polychlorinated biphenyls, sperm chromatin integrity, sperm chromatin structure assay (SCSA). Environ Health Perspect 113:175?179 (2005). doi:10.1289/ehp.7252 [22 November 2004].


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