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Effect of Diet on the Hepatotoxicity-Of Polybrominated Biphenyls (Fire Master Pb-6)

By Babish, J. G.

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Book Id: WPLBN0000209951
Format Type: PDF eBook
File Size: 0.3 MB
Reproduction Date: 2005

Title: Effect of Diet on the Hepatotoxicity-Of Polybrominated Biphenyls (Fire Master Pb-6)  
Author: Babish, J. G.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Babish, J. G. (n.d.). Effect of Diet on the Hepatotoxicity-Of Polybrominated Biphenyls (Fire Master Pb-6). Retrieved from

Government Reference Publication

Excerpt: Excretion of exogenous, lipid-soluble compounds is generally initiated by the microsomal mixedfunction oxidase (MFO) system operating in many tissues throughout the body. The MFO system certainly existed long before the advent of modern drugs and environmental pollution, yet their natural role has received little attention. It is generally believed that evolutionary development of the MFO system occurred to counteract the chemical defenses of many plant species (1) . Plants accumulate many secondary substances-chemicals that do not That the consumption of certain vegetables can affect the level of MFO activity has been demonstrated by several researchers (2, 3). The most potent vegetables for inducing MFO activity are members of the Brussicuceae family, including Brussels sprouts, cabbage, turnips, broccoli, and cauliflower. Inducing activity has also been observed in spinach, dill, and celery (2.4). This study was designed to determine if the quantitative changes in MFO activity observed when certain MFO inducing vegetables are present - participate in the basic metabolism of the plant. in the diet affect qualitative changes in the hepatic Among these are many chemicals that serve to repel response to polybrominated biphenyls (PBB). or discourage the use of the plant by insects, microorganisms, grazing animals and man.


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