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Metabolomics : Whats Happening Downstreamof Dna

By Schmidt, Charles W.

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Book Id: WPLBN0000211341
Format Type: PDF eBook
File Size: 6.6 MB
Reproduction Date: 2005

Title: Metabolomics : Whats Happening Downstreamof Dna  
Author: Schmidt, Charles W.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Schmidt, C. W. (n.d.). Metabolomics : Whats Happening Downstreamof Dna. Retrieved from

Government Reference Publication

Excerpt: The decoding of the human genome gave rise to genomics and proteomics?? global? studies of genes and proteins, respectively?which are often touted in terms of their enormous clinical potential. In the midst of a growing shift toward translational studies in todays biomedical research scene, yet another ?-omics? science has come to the fore. The science is called metabolomics, and its protagonists say it offers a cheap, rapid, and effective way to diagnose illness and monitor patient therapy. Metabolomics is the study of metabolite profiles in biological samples, particularly urine, saliva, and blood plasma; scientists are interested in all, rather than some, of the metabolites in a given sample. Metabolites are the by-products of metabolism, which is itself the process of converting food energy to mechanical energy or heat. The number of different metabolites in the human is unknown; estimates range from a low of 2,000?3,000 to a high of around 20,000, compared to an estimated 30,000 genes and 100,000 proteins. Of particular interest to metabolomics researchers are small, low-molecular-weight compounds that serve as substrates and products in various metabolic pathways. These ?small molecules,? as they are called, include compounds such as lipids, sugars, and amino acids that can provide important clues about the individuals health.


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