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Cadmium, Mercury, And Lead in Kidney Cortex of the General Swedish Population : A Study of Biopsies from Living Kidney Donors

By Barregard, Lars

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Book Id: WPLBN0000213515
Format Type: PDF eBook
File Size: 0.2 MB
Reproduction Date: 2005

Title: Cadmium, Mercury, And Lead in Kidney Cortex of the General Swedish Population : A Study of Biopsies from Living Kidney Donors  
Author: Barregard, Lars
Volume:
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Historic
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Publisher: United Nations- Office for Disarmament Affairs (Unoda)

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Barregard, L. (n.d.). Cadmium, Mercury, And Lead in Kidney Cortex of the General Swedish Population : A Study of Biopsies from Living Kidney Donors. Retrieved from http://www.ebooklibrary.org/


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Government Reference Publication

Excerpt
Excerpt: Cadmium, mercury, and lead concentrations were determined in deep-frozen kidney cortex biopsies taken from 36 living, healthy Swedish kidney donors (18 males and 18 females), who were 30?71 (mean 53) years of age. Information about occupation, smoking, the presence of dental amalgam, and fish consumption could be obtained for 27 of the donors. The samples (median dry weight 0.74 mg) were analyzed using inductively coupled plasma mass spectrometry, and the results were transformed to wet-weight concentrations. The median kidney Cd was 17 micrograms/g (95% confidence interval, 14?23 micrograms/g), which was similar in males and females. In 10 active smokers, the median kidney Cd was 24 micrograms/g, and in 12 who never smoked, it was 17 micrograms/g. The median kidney Hg was 0.29 micrograms/g, with higher levels in females (median 0.54 micrograms/g) than in males (median 0.16 micrograms/g). Subjects with amalgam fillings had higher kidney Hg (median 0.47 micrograms/g, n = 20) than those without dental amalgam (median 0.15 micrograms/g, n = 6), but kidney Hg was below the detection limit in some samples. Nearly half of the samples had kidney Pb below the detection limit. The median kidney Pb was estimated as 0.14 micrograms/g. This is the first study of heavy metals in kidney cortex of living, healthy subjects, and the results are relatively similar to those of a few previous autopsy studies, indicating that results from autopsy cases are not seriously biased in relation to kidney metal concentrations in the general population. Cd concentrations in those who never smoked were relatively high, indicating considerable Cd intake from the diet in Sweden. The effect of dental amalgam on kidney Hg was as expected, although the reason for the difference in Hg levels between males and females is unclear. Key words: biopsy, cadmium, heavy metals, kidney, kidney donors, lead, mercury, renal cortex.


 

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