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Polychlorinated Biphenyls and Methylmercury Act Synergistically to Reduce Rat Brain Dopamine Content in Vitro

By Bemis, Jeffrey C.

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Book Id: WPLBN0000217026
Format Type: PDF eBook
File Size: 0.2 MB
Reproduction Date: 2005

Title: Polychlorinated Biphenyls and Methylmercury Act Synergistically to Reduce Rat Brain Dopamine Content in Vitro  
Author: Bemis, Jeffrey C.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Bemis, J. C. (n.d.). Polychlorinated Biphenyls and Methylmercury Act Synergistically to Reduce Rat Brain Dopamine Content in Vitro. Retrieved from

Government Reference Publication

Excerpt: Consumption of contaminated Great Lakes fish by pregnant women is associated with decreased birth weight and deficits in cognitive function in their infants and children. These fish contain many known and suspected anthropogenic neurotoxicants, making it difficult to determine which contaminant(s) are responsible for the observed deficits. We have undertaken a series of experiments to determine the relevant toxicants by comparing the neurotoxic effects of two of these contaminants?polychlorinated biphenyls (PCBs) and methylmercury (MeHg)?both of which are recognized neurotoxicants. Striatal punches obtained from adult rat brain were exposed to PCBs only, MeHg only, or the two in combination, and tissue and media concentrations of dopamine (DA) and its metabolites were determined by high performance liquid chromatography. Exposure to PCBs only reduced tissue DA and elevated media DA in a dose-dependent fashion. Exposure to MeHg only did not significantly affect either measure. However, when striatal punches were simultaneously exposed to PCBs and MeHg, there were significantly greater decreases in tissue DA concentrations and elevations in media DA than those caused by PCBs only, in the absence of changes in media lactate dehydrogenase concentrations. Elevations in both tissue and media 3,4-dihydroxyphenylacetic acid concentrations were also observed. We suggest that the significant interactions between these two toxicants may be due to a common site of action (i.e., toxicant-induced increases in intracellular calcium and changes in second messenger systems) that influences DA function. The synergism between these contaminants suggests that future revisions of fish-consumption guidelines should consider contaminant interactions. Key words: dopamine, methylmercury, polychlorinated biphenyls, rat brain, striatal slice, synergism. Environ Health Perspect 107:879?885 (1999). [7 October 1999].


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