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Modulation of Tumor Promotion in Liver Carcinogenesis

By Shinozuka, Hisashi

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Book Id: WPLBN0000220481
Format Type: PDF eBook
File Size: 0.3 MB
Reproduction Date: 2005

Title: Modulation of Tumor Promotion in Liver Carcinogenesis  
Author: Shinozuka, Hisashi
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Shinozuka, H. (n.d.). Modulation of Tumor Promotion in Liver Carcinogenesis. Retrieved from

Government Reference Publication

Excerpt: Earlier, we demonstrated that feeding a diet devoid of choline, a lipotropic factor, markedly enhanced liver tumor induction in rats by several chemical carcinogens either included in the cholinedevoid iCD) diet or administered while rats were on the CD diet (1-3). Further studies showed that feeding the CD diet strongly promotes the evolution of liver cells, initiated by chemical carcinogens, to foci of y glutamyl transpeptidase-iGGT +) positive hepatocytes (4)a nd the evolution of the foci to hepatomas (5). Thus, the action of a CD diet is very similar to that of phenobarbital (PHB) which has been shown to be also an effective promoter of liver carcinogenesis (6-91.


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