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Dna Adducts of Propylene Oxide and Acrylonitrile Epoxide : Hydrolytic Deamination of 3-Alkyl-Dcyd to 3-Alkyl-Durd

By Solomon, Jerome J.

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Book Id: WPLBN0000226116
Format Type: PDF eBook
File Size: 0.3 MB
Reproduction Date: 2005

Title: Dna Adducts of Propylene Oxide and Acrylonitrile Epoxide : Hydrolytic Deamination of 3-Alkyl-Dcyd to 3-Alkyl-Durd  
Author: Solomon, Jerome J.
Volume:
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Historic
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Publisher: United Nations- Office for Disarmament Affairs (Unoda)

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Solomon, J. J. (n.d.). Dna Adducts of Propylene Oxide and Acrylonitrile Epoxide : Hydrolytic Deamination of 3-Alkyl-Dcyd to 3-Alkyl-Durd. Retrieved from http://www.ebooklibrary.org/


Description
Government Reference Publication

Excerpt
Introduction: A major goal of modern molecular cancer epidemiology is to improve the estimates of exposure to environmental factors (1). Exposure assessment has traditionally been based on unreliable measures such as answers to questionnaires and the measurement of ambient levels of pollutants. These estimates of exposure are limited because of individual differences in uptake, distniution, and metabolism of carcinogens. Iridividual biological measurements could in principle correct for these differences if the critical biological event caused by a carcinogen could be monitored. A major breakthrough in the field of chemical carcinogenesis was the realization that carcinogens or their metabolites combine with cellular constituents such as DNA to exert their biological effects (2). Reactions of carcinogens or carcinogen metabolites with DNA are believed to be responsible for the mutagenic action and possibly the initiation of malignant change of a wide.

 

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