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Specificity of the Effects of Lead on Brain Energy Metabolism for Substrates Donating a Cytoplasmic Reducing Equivalent

By Bull, Richard J.

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Book Id: WPLBN0000231362
Format Type: PDF eBook
File Size: 0.4 MB
Reproduction Date: 2005

Title: Specificity of the Effects of Lead on Brain Energy Metabolism for Substrates Donating a Cytoplasmic Reducing Equivalent  
Author: Bull, Richard J.
Volume:
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Historic
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)

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Bull, R. J. (n.d.). Specificity of the Effects of Lead on Brain Energy Metabolism for Substrates Donating a Cytoplasmic Reducing Equivalent. Retrieved from http://www.ebooklibrary.org/


Description
Government Reference Publication

Excerpt
Introduction: The picture developed in animal models of lead encephalopathy involves a primary lesion in cerebellar capillaries which is followed by degenerative changes in astrocytic foot processes and then neuronal degeneration (I). This sequence of events is taken to indicate that alterations of the blond-brain barrier to lead is the initial insult in the development of lesions in young animals. However, as Michaelson and Sauerhoff (2) have pointed out, the production of these changes requires very high doses of lead and results in gross abnormalities of nervous system function.

 

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