World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

The Roles of Serum Selenium and Selenoproteins on Mercury Toxicity in Environmental and Occupational Exposure

By Chen, Chunying

Click here to view

Book Id: WPLBN0000238523
Format Type: PDF eBook
File Size: 0.2 MB
Reproduction Date: 2005

Title: The Roles of Serum Selenium and Selenoproteins on Mercury Toxicity in Environmental and Occupational Exposure  
Author: Chen, Chunying
Volume:
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Historic
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)

Citation

APA MLA Chicago

Chen, C. (n.d.). The Roles of Serum Selenium and Selenoproteins on Mercury Toxicity in Environmental and Occupational Exposure. Retrieved from http://www.ebooklibrary.org/


Description
Government Reference Publication

Excerpt
Excerpt: Many studies have found that mercury (Hg) exposure is associated with selenium (Se) accumulation in vivo. However, human studies are limited. To study the interaction between Se and Hg, we investigated the total Se and Hg concentrations in body fluids and serum Se-containing proteins in individuals exposed to high concentrations of Hg. Our objective was to elucidate the possible roles of serum Se and selenoproteins in transporting and binding Hg in human populations. We collected data from 72 subjects: 35 had very low Hg exposure as evidenced by mean Hg concentrations of 0.91 and 1.25 ng/mL measured in serum and urine, respectively; 37 had high exposure (mean Hg concentrations of 38.5 and 86.8 ng/mL measured in serum and urine, respectively). An association between Se and Hg was found in urine (r = 0.625; p < 0.001) but not in serum. Hg exposure may affect Se concentrations and selenoprotein distribution in human serum. Expression of both selenoprotein P and glutathione peroxidase (GSH-Px) was greatly increased in Hg miners. These increases were accompanied by elevated Se concentrations in serum. In addition, selenoprotein P bound more Hg at higher Hg exposure concentrations. Biochemical observations revealed that both GSH-Px activity and malondialdehyde concentrations increased in serum of the Hg-exposed group. This study aids in the understanding of the interaction between Se and Hg. Selenoproteins play two important roles in protecting against Hg toxicity. First, they may bind more Hg through their highly reactive selenol group, and second, their antioxidative properties help eliminate the reactive oxygen species induced by Hg in vivo. Key words: antagonism, Hg-exposed subjects, mercury, selenium, selenoproteins, serum.


 

Click To View

Additional Books


  • The Sex Difference in Tumor Incidence Is... (by )
  • Cancer Mortality in U. S. Counties with ... (by )
  • Chronological Supplement to the Carcinog... (by )
  • Correlation between Blood Ethylenethiour... (by )
  • Organotins Disrupt the 11Beta-Hydroxyste... (by )
  • Aneuploidy as a Human Health Problem of ... (by )
  • Exposure to Halogenated Hydrocarbons in ... (by )
  • Adjusting for Youth Updated Cancer Risk ... (by )
  • Approach to Risk Assessment for Genotoxi... (by )
  • Environmental Correlates of Intercity Va... (by )
  • Environmental Medicine at a Crossroad : ... (by )
  • Health and Community Design : The Impact... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.