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Plos Genetics : Making Ends Meet ; Repairing Breaks in Bacterial Dna by Non-homologous End-joining, Volume 2

By Bowater, Richard

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Book Id: WPLBN0003923394
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Genetics : Making Ends Meet ; Repairing Breaks in Bacterial Dna by Non-homologous End-joining, Volume 2  
Author: Bowater, Richard
Volume: Volume 2
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

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Bowater, R. (n.d.). Plos Genetics : Making Ends Meet ; Repairing Breaks in Bacterial Dna by Non-homologous End-joining, Volume 2. Retrieved from http://www.ebooklibrary.org/


Description
Description : DNA double-strand breaks (DSBs) are one of the most dangerous forms of DNA lesion that can result in genomic instability and cell death. Therefore cells have developed elaborate DSB-repair pathways to maintain the integrity of genomic DNA. There are two major pathways for the repair of DSBs in eukaryotes : homologous recombination and non-homologous end-joining (NHEJ). Until very recently, the NHEJ pathway had been thought to be restricted to the eukarya. However, an evolutionarily related NHEJ apparatus has now been identified and characterized in the prokarya. Here we review the recent discoveries concerning bacterial NHEJ and discuss the possible origins of this repair system. We also examine the insights gained from the recent cellular and biochemical studies of this DSB-repair process and discuss the possible cellular roles of an NHEJ pathway in the life-cycle of prokaryotes and phages.

 

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