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Plos Genetics : Selection Acts on Dna Secondary Structures to Decrease Transcriptional Mutagenesis, Volume 2

By Gojobori, Takashi

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Book Id: WPLBN0003923434
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Genetics : Selection Acts on Dna Secondary Structures to Decrease Transcriptional Mutagenesis, Volume 2  
Author: Gojobori, Takashi
Volume: Volume 2
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

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Gojobori, T. (n.d.). Plos Genetics : Selection Acts on Dna Secondary Structures to Decrease Transcriptional Mutagenesis, Volume 2. Retrieved from http://www.ebooklibrary.org/


Description
Description : Single-stranded DNA is more subject to mutation than double stranded. During transcription, DNA is transiently single stranded and therefore subject to higher mutagenesis. However, if local intra-strand secondary structures are formed, some bases will be paired and therefore less sensitive to mutation than unpaired bases. Using complete genome sequences of Escherichia coli, we show that local intra-strand secondary structures can, as a consequence, be used to define an index of transcription-driven mutability. At gene level, we show that natural selection has favoured a reduced transcription-driven mutagenesis via the higher than expected frequency of occurrence of intra-strand secondary structures. Such selection is stronger in highly expressed genes and suggests a sequence-dependent way to control mutation rates and a novel form of selection affecting the evolution of synonymous mutations.

 

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