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Plos Genetics : the Glut9 Gene is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts, Volume 3

By Allison, David B.

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Book Id: WPLBN0003924657
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Genetics : the Glut9 Gene is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts, Volume 3  
Author: Allison, David B.
Volume: Volume 3
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

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Allison, D. B. (n.d.). Plos Genetics : the Glut9 Gene is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts, Volume 3. Retrieved from http://www.ebooklibrary.org/


Description
Description : High serum uric acid levels elevate pro-inflammatory–state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p ¼ 1.84 3 10 16), along with eight others (p ¼ 7.75 3 10 16 to 6.05 3 10 11). Individuals homozygous for the rare allele of rs6855911 (minor allele frequency ¼ 0.26) had 0.6 mg/dl less uric acid than those homozygous for the common allele: the results were replicated in an unrelated cohort from Tuscany. Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values.


 

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