World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Biology : Structural Basis of Competitive Recognition of P53 and Mdm2 by Hausp, Volume 4

By Petsko, Greg

Click here to view

Book Id: WPLBN0003925496
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Biology : Structural Basis of Competitive Recognition of P53 and Mdm2 by Hausp, Volume 4  
Author: Petsko, Greg
Volume: Volume 4
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Publication Date:
Publisher: Plos


APA MLA Chicago

Petsko, G. (n.d.). Plos Biology : Structural Basis of Competitive Recognition of P53 and Mdm2 by Hausp, Volume 4. Retrieved from

Description : Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7), a deubiquitylating enzyme of the ubiquitin-specific processing protease family, specifically deubiquitylates both p53 and MDM2, hence playing an important yet enigmatic role in the p53–MDM2 pathway. Here we demonstrate that both p53 and MDM2 specifically recognize the N-terminal tumor necrosis factor–receptor associated factor (TRAF)–like domain of HAUSP in a mutually exclusive manner. HAUSP preferentially forms a stable HAUSP–MDM2 complex even in the presence of excess p53. The HAUSP-binding elements were mapped to a peptide fragment in the carboxy-terminus of p53 and to a short-peptide region preceding the acidic domain of MDM2. The crystal structures of the HAUSP TRAF-like domain in complex with p53 and MDM2 peptides, determined at 2.3-A° and 1.7-A° resolutions, respectively, reveal that the MDM2 peptide recognizes the same surface groove in HAUSP as that recognized by p53 but mediates more extensive interactions. Structural comparison led to the identification of a consensus peptide-recognition sequence by HAUSP. These results, together with the structure of a combined substrate-binding-and-deubiquitylation domain of HAUSP, provide important insights into regulation of the p53–MDM2 pathway by HAUSP.


Click To View

Additional Books

  • Plos Biology : Exon Silencing by Uagg Mo... (by )
  • Plos Biology : Integrated Electron Micro... (by )
  • Plos Biology : Induction of Biogenic Mag... (by )
  • Plos Biology : Evolutionarily Repurposed... (by )
  • Plos Biology : Variants in a Novel Epide... (by )
  • Plos Biology : Evolutionarily Conserved ... (by )
  • Plos Biology : Use of a Dense Single Nuc... (by )
  • Plos Biology : Alternative Splicing of R... (by )
  • Plos Biology : Robust Target Gene Discov... (by )
  • Plos Biology : the Geographic Spread of ... (by )
  • Plos Biology : Partial Inhibition of Adi... (by )
  • Plos Biology : Amplification of Trial-to... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.