World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : How to Perform Meaningful Estimates of Genetic Effects, Volume 4

By Allison, David B.

Click here to view

Book Id: WPLBN0003926021
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : How to Perform Meaningful Estimates of Genetic Effects, Volume 4  
Author: Allison, David B.
Volume: Volume 4
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Publication Date:
Publisher: Plos


APA MLA Chicago

Allison, D. B. (n.d.). Plos Genetics : How to Perform Meaningful Estimates of Genetic Effects, Volume 4. Retrieved from

Description : Although the genotype-phenotype map plays a central role both in Quantitative and Evolutionary Genetics, the formalization of a completely general and satisfactory model of genetic effects, particularly accounting for epistasis, remains a theoretical challenge. Here, we use a two-locus genetic system in simulated populations with epistasis to show the convenience of using a recently developed model, NOIA, to perform estimates of genetic effects and the decomposition of the genetic variance that are orthogonal even under deviations from the Hardy-Weinberg proportions. We develop the theory for how to use this model in interval mapping of quantitative trait loci using Halley-Knott regressions, and we analyze a real data set to illustrate the advantage of using this approach in practice. In this example, we show that departures from the Hardy-Weinberg proportions that are expected by sampling alone substantially alter the orthogonal estimates of genetic effects when other statistical models, like F2 or G2A, are used instead of NOIA. Finally, for the first time from real data, we provide estimates of functional genetic effects as sets of effects of natural allele substitutions in a particular genotype, which enriches the debate on the interpretation of genetic effects as implemented both in functional and in statistical models. We also discuss further implementations leading to a completely general genotype-phenotype map. O¨


Click To View

Additional Books

  • Plos Genetics : Quantitative Models of t... (by )
  • Plos Genetics : the Human Pancreatic Isl... (by )
  • Plos Genetics : Understanding Mammalian ... (by )
  • Plos Genetics : Rewiring of Pdz Domain-l... (by )
  • Plos Genetics : the Maternal-effect Gene... (by )
  • Plos Genetics : Combinatorial Regulation... (by )
  • Plos Genetics : Sox2 Co-occupies Distal ... (by )
  • Plos Genetics : Alu Recombination-mediat... (by )
  • Plos Genetics : Divergent Selection Driv... (by )
  • Plos Genetics : Genome-wide Association ... (by )
  • Plos Genetics : Rapid Turnover of Long N... (by )
  • Plos Genetics : the Potential for Enhanc... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.