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Plos Genetics : Resolving Individuals Contributing Trace Amounts of Dna to Highly Complex Mixtures Using High-density Snp Genotyping Microarrays, Volume 4

By Visscher, Peter M.

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Book Id: WPLBN0003926109
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Genetics : Resolving Individuals Contributing Trace Amounts of Dna to Highly Complex Mixtures Using High-density Snp Genotyping Microarrays, Volume 4  
Author: Visscher, Peter M.
Volume: Volume 4
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection, PLoS Genetics
Historic
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Publisher: Plos

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Visscher, P. M. (n.d.). Plos Genetics : Resolving Individuals Contributing Trace Amounts of Dna to Highly Complex Mixtures Using High-density Snp Genotyping Microarrays, Volume 4. Retrieved from http://www.ebooklibrary.org/


Description
Description : We use high-density single nucleotide polymorphism (SNP) genotyping microarrays to demonstrate the ability to accurately and robustly determine whether individuals are in a complex genomic DNA mixture. We first develop a theoretical framework for detecting an individual’s presence within a mixture, then show, through simulations, the limits associated with our method, and finally demonstrate experimentally the identification of the presence of genomic DNA of specific individuals within a series of highly complex genomic mixtures, including mixtures where an individual contributes less than 0.1% of the total genomic DNA. These findings shift the perceived utility of SNPs for identifying individual trace contributors within a forensics mixture, and suggest future research efforts into assessing the viability of previously sub-optimal DNA sources due to sample contamination. These findings also suggest that composite statistics across cohorts, such as allele frequency or genotype counts, do not mask identity within genome-wide association studies. The implications of these findings are discussed.


 

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