World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Biology : Myc Dynamically and Preferentially Relocates to a Transcription Factory Occupied by Igh, Volume 5

By Gasser, Susan M

Click here to view

Book Id: WPLBN0003927053
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Biology : Myc Dynamically and Preferentially Relocates to a Transcription Factory Occupied by Igh, Volume 5  
Author: Gasser, Susan M
Volume: Volume 5
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Biology
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Gasser, S. M. (n.d.). Plos Biology : Myc Dynamically and Preferentially Relocates to a Transcription Factory Occupied by Igh, Volume 5. Retrieved from http://www.ebooklibrary.org/


Description
Description : Transcription in mammalian nuclei is highly compartmentalized in RNA polymerase II-enriched nuclear foci known as transcription factories. Genes in cis and trans can share the same factory, suggesting that genes migrate to preassembled transcription sites. We used fluorescent in situ hybridization to investigate the dynamics of gene association with transcription factories during immediate early (IE) gene induction in mouse B lymphocytes. Here, we show that induction involves rapid gene relocation to transcription factories. Importantly, we find that the Myc protooncogene on Chromosome 15 is preferentially recruited to the same transcription factory as the highly transcribed Igh gene located on Chromosome 12. Myc and Igh are the most frequent translocation partners in plasmacytoma and Burkitt lymphoma. Our results show that transcriptional activation of IE genes involves rapid relocation to preassembled transcription factories. Furthermore, the data imply a direct link between the nonrandom interchromosomal organization of transcribed genes at transcription factories and the incidence of specific chromosomal translocations.

 

Click To View

Additional Books


  • Plos Biology : Unraveling the Molecular ... (by )
  • Plos Biology : the Vestibular System Imp... (by )
  • Plos Biology : Clathrin Couture ; Fashio... (by )
  • Plos Biology : Segregation of Odor Ident... (by )
  • Plos Biology : How Bacteria Shift Gears,... (by )
  • Plos Biology : Stat5 Signaling Specifies... (by )
  • Plos Biology : Effects of Resveratrol an... (by )
  • Plos Biology : Jumping Genes Reveal Kang... (by )
  • Plos Biology : Mimotopes for Alloreactiv... (by )
  • Plos Biology : Open Engagement ; Explori... (by )
  • Plos Biology : Quantitative Analysis of ... (by )
  • Plos Biology : Patterns of Intron Gain a... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.