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Plos Genetics : Assessing the Impact of Transgenerational Epigenetic Variation on Complex Traits, Volume 5

By Visscher, Peter M.

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Book Id: WPLBN0003927629
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Genetics : Assessing the Impact of Transgenerational Epigenetic Variation on Complex Traits, Volume 5  
Author: Visscher, Peter M.
Volume: Volume 5
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

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Visscher, P. M. (n.d.). Plos Genetics : Assessing the Impact of Transgenerational Epigenetic Variation on Complex Traits, Volume 5. Retrieved from http://www.ebooklibrary.org/


Description
Description : Loss or gain of DNA methylation can affect gene expression and is sometimes transmitted across generations. Such epigenetic alterations are thus a possible source of heritable phenotypic variation in the absence of DNA sequence change. However, attempts to assess the prevalence of stable epigenetic variation in natural and experimental populations and to quantify its impact on complex traits have been hampered by the confounding effects of DNA sequence polymorphisms. To overcome this problem as much as possible, two parents with little DNA sequence differences, but contrasting DNA methylation profiles, were used to derive a panel of epigenetic Recombinant Inbred Lines (epiRILs) in the reference plant Arabidopsis thaliana. The epiRILs showed variation and high heritability for flowering time and plant height (,30%), as well as stable inheritance of multiple parental DNA methylation variants (epialleles) over at least eight generations. These findings provide a first rationale to identify epiallelic variants that contribute to heritable variation in complex traits using linkage or association studies. More generally, the demonstration that numerous epialleles across the genome can be stable over many generations in the absence of selection or extensive DNA sequence variation highlights the need to integrate epigenetic information into population genetics studies.


 

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