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Plos Genetics : Escherichia Colimazf Leads to the Simultaneous Selective Synthesis of Both ‘‘death Proteins’’ and ‘‘survival Proteins’’, Volume 5

By Rosenberg, Susan M.

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Book Id: WPLBN0003927708
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Genetics : Escherichia Colimazf Leads to the Simultaneous Selective Synthesis of Both ‘‘death Proteins’’ and ‘‘survival Proteins’’, Volume 5  
Author: Rosenberg, Susan M.
Volume: Volume 5
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

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Rosenberg, S. M. (n.d.). Plos Genetics : Escherichia Colimazf Leads to the Simultaneous Selective Synthesis of Both ‘‘death Proteins’’ and ‘‘survival Proteins’’, Volume 5. Retrieved from http://www.ebooklibrary.org/


Description
Description : The Escherichia coli mazEF module is one of the most thoroughly studied toxin–antitoxin systems. mazF encodes a stable toxin, MazF, and mazE encodes a labile antitoxin, MazE, which prevents the lethal effect of MazF. MazF is an endoribonuclease that leads to the inhibition of protein synthesis by cleaving mRNAs at ACA sequences. Here, using 2Dgels, we show that in E. coli, although MazF induction leads to the inhibition of the synthesis of most proteins, the synthesis of an exclusive group of proteins, mostly smaller than about 20 kDa, is still permitted. We identified some of those small proteins by mass spectrometry. By deleting the genes encoding those proteins from the E. coli chromosome, we showed that they were required for the death of most of the cellular population. Under the same experimental conditions, which induce mazEF-mediated cell death, other such proteins were found to be required for the survival of a small sub-population of cells. Thus, MazF appears to be a regulator that induces downstream pathways leading to death of most of the population and the continued survival of a small sub-population, which will likely become the nucleus of a new population when growth conditions become less stressful.

 

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