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Plos Genetics : Genome-wide Association Scan Meta-analysis Identifies Three Loci Influencing Adiposity and Fat Distribution, Volume 5

By Allison, David B.

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Book Id: WPLBN0003927759
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Genetics : Genome-wide Association Scan Meta-analysis Identifies Three Loci Influencing Adiposity and Fat Distribution, Volume 5  
Author: Allison, David B.
Volume: Volume 5
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

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Allison, D. B. (n.d.). Plos Genetics : Genome-wide Association Scan Meta-analysis Identifies Three Loci Influencing Adiposity and Fat Distribution, Volume 5. Retrieved from http://www.ebooklibrary.org/


Description
Description : To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity: these map near TFAP2B (WC, P = 1.9610211) and MSRA (WC, P = 8.961029). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.661028). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.


 

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