World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : Accurately Assessing the Risk of Schizophrenia Conferred by Rare Copy-number Variation Affecting Genes with Brain Function, Volume 6

By Allison, David B.

Click here to view

Book Id: WPLBN0003929504
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : Accurately Assessing the Risk of Schizophrenia Conferred by Rare Copy-number Variation Affecting Genes with Brain Function, Volume 6  
Author: Allison, David B.
Volume: Volume 6
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Allison, D. B. (n.d.). Plos Genetics : Accurately Assessing the Risk of Schizophrenia Conferred by Rare Copy-number Variation Affecting Genes with Brain Function, Volume 6. Retrieved from http://www.ebooklibrary.org/


Description
Description : Investigators have linked rare copy number variation (CNVs) to neuropsychiatric diseases, such as schizophrenia. One hypothesis is that CNV events cause disease by affecting genes with specific brain functions. Under these circumstances, we expect that CNV events in cases should impact brain-function genes more frequently than those events in controls. Previous publications have applied ‘‘pathway’’ analyses to genes within neuropsychiatric case CNVs to show enrichment for brainfunctions. While such analyses have been suggestive, they often have not rigorously compared the rates of CNVs impacting genes with brain function in cases to controls, and therefore do not address important confounders such as the large size of brain genes and overall differences in rates and sizes of CNVs. To demonstrate the potential impact of confounders, we genotyped rare CNV events in 2,415 unaffected controls with Affymetrix 6.0: we then applied standard pathway analyses using four sets of brain-function genes and observed an apparently highly significant enrichment for each set. The enrichment is simply driven by the large size of brain-function genes. Instead, we propose a case-control statistical test, cnvenrichment- test, to compare the rate of CNVs impacting specific gene sets in cases versus controls. With simulations, we demonstrate that cnv-enrichment-test is robust to case-control differences in CNV size, CNV rate, and systematic differences in gene size. Finally, we apply cnv-enrichment-test to rare CNV events published by the International Schizophrenia Consortium (ISC). This approach reveals nominal evidence of case-association in neuronal-activity and the learning gene sets, but not the other two examined gene sets. The neuronal-activity genes have been associated in a separate set of schizophrenia cases and controls: however, testing in independent samples is necessary to definitively confirm this association. Our method is implemented in the PLINK software package.


 

Click To View

Additional Books


  • Plos Genetics : a Pol V–mediated Silenci... (by )
  • Plos Genetics : the Arabidopsis Blap75, ... (by )
  • Plos Genetics : Linkage and Association ... (by )
  • Plos Genetics : Hypersensitive to Red an... (by )
  • Plos Genetics : Genetic and Linguistic C... (by )
  • Plos Genetics : Distinct Roles and Regul... (by )
  • Plos Genetics : Genetic Screens for Muta... (by )
  • Plos Genetics : Fhy1 Mediates Nuclear Im... (by )
  • Plos Genetics : Escherichia Colimazf Lea... (by )
  • Plos Genetics : Genome Instability and T... (by )
  • Plos Genetics : Independent Evolution of... (by )
  • Plos Genetics : Substitutions in the Ami... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.