World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : Evidence for Pervasive Adaptive Protein Evolution in Wild Mice, Volume 6

By Nachman, Michael W.

Click here to view

Book Id: WPLBN0003929650
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : Evidence for Pervasive Adaptive Protein Evolution in Wild Mice, Volume 6  
Author: Nachman, Michael W.
Volume: Volume 6
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Nachman, M. W. (n.d.). Plos Genetics : Evidence for Pervasive Adaptive Protein Evolution in Wild Mice, Volume 6. Retrieved from http://www.ebooklibrary.org/


Description
Description : The relative contributions of neutral and adaptive substitutions to molecular evolution has been one of the most controversial issues in evolutionary biology for more than 40 years. The analysis of within-species nucleotide polymorphism and between-species divergence data supports a widespread role for adaptive protein evolution in certain taxa. For example, estimates of the proportion of adaptive amino acid substitutions (a) are 50% or more in enteric bacteria and Drosophila. In contrast, recent estimates of a for hominids have been at most 13%. Here, we estimate a for protein sequences of murid rodents based on nucleotide polymorphism data from multiple genes in a population of the house mouse subspecies Mus musculus castaneus, which inhabits the ancestral range of the Mus species complex and nucleotide divergence between M. m. castaneus and M. famulus or the rat. We estimate that 57% of amino acid substitutions in murids have been driven by positive selection. Hominids, therefore, are exceptional in having low apparent levels of adaptive protein evolution. The high frequency of adaptive amino acid substitutions in wild mice is consistent with their large effective population size, leading to effective natural selection at the molecular level. Effective natural selection also manifests itself as a paucity of effectively neutral nonsynonymous mutations in M. m. castaneus compared to humans.

 

Click To View

Additional Books


  • Plos Genetics : Zebrafish Edaand Edarmut... (by )
  • Plos Genetics : Uncoupling of Satellite ... (by )
  • Plos Genetics : the Maternal-effect Gene... (by )
  • Plos Genetics : Heterozygous Mutations o... (by )
  • Plos Genetics : Association of Variants ... (by )
  • Plos Genetics : B Chromosomes Have a Fun... (by )
  • Plos Genetics : Evidence of Gene–environ... (by )
  • Plos Genetics : 1+1 = 3 ; a Fusion of 2 ... (by )
  • Plos Genetics : the Epistatic Relationsh... (by )
  • Plos Genetics : Mos11 ; a New Component ... (by )
  • Plos Genetics : a S+c766Red Role for Rbf... (by )
  • Plos Genetics : a Cholinergic-regulated ... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.