World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : a Conserved Developmental Patterning Network Produces Quantitatively Different Output in Multiple Species of Drosophila, Volume 7

By Kopp, Artyom

Click here to view

Book Id: WPLBN0003931360
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : a Conserved Developmental Patterning Network Produces Quantitatively Different Output in Multiple Species of Drosophila, Volume 7  
Author: Kopp, Artyom
Volume: Volume 7
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Kopp, A. (n.d.). Plos Genetics : a Conserved Developmental Patterning Network Produces Quantitatively Different Output in Multiple Species of Drosophila, Volume 7. Retrieved from http://www.ebooklibrary.org/


Description
Description : Differences in the level, timing, or location of gene expression can contribute to alternative phenotypes at the molecular and organismal level. Understanding the origins of expression differences is complicated by the fact that organismal morphology and gene regulatory networks could potentially vary even between closely related species. To assess the scope of such changes, we used high-resolution imaging methods to measure mRNA expression in blastoderm embryos of Drosophila yakuba and Drosophila pseudoobscura and assembled these data into cellular resolution atlases, where expression levels for 13 genes in the segmentation network are averaged into species-specific, cellular resolution morphological frameworks. We demonstrate that the blastoderm embryos of these species differ in their morphology in terms of size, shape, and number of nuclei. We present an approach to compare cellular gene expression patterns between species, while accounting for varying embryo morphology, and apply it to our data and an equivalent dataset for Drosophila melanogaster. Our analysis reveals that all individual genes differ quantitatively in their spatio-temporal expression patterns between these species, primarily in terms of their relative position and dynamics. Despite many small quantitative differences, cellular gene expression profiles for the whole set of genes examined are largely similar. This suggests that cell types at this stage of development are conserved, though they can differ in their relative position by up to 3–4 cell widths and in their relative proportion between species by as much as 5-fold. Quantitative differences in the dynamics and relative level of a subset of genes between corresponding cell types may reflect altered regulatory functions between species. Our results emphasize that transcriptional networks can diverge over short evolutionary timescales and that even small changes can lead to distinct output in terms of the placement and number of equivalent cells.

 

Click To View

Additional Books


  • Plos Genetics : Natural Single-nucleosom... (by )
  • Plos Genetics : Comparative Genomics of ... (by )
  • Plos Genetics : Neutral Genomic Microevo... (by )
  • Plos Genetics : a Mystery Unraveled ; Es... (by )
  • Plos Genetics : Evaluating Statistical M... (by )
  • Plos Genetics : Distinguishing Between S... (by )
  • Plos Genetics : Genetic Architecture of ... (by )
  • Plos Genetics : Gene Copy-number Polymor... (by )
  • Plos Genetics : Finished Genome of the F... (by )
  • Plos Genetics : the Conserved Intronic C... (by )
  • Plos Genetics : Genetic Basis of Growth ... (by )
  • Plos Genetics : Trar, a Homolog of a Rna... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.