World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : Evolution of Vertebrate Transient Receptor Potential Vanilloid 3 Channels ; Opposite Temperature Sensitivity Between Mammals and Western Clawed Frogs, Volume 7

By Zhang, Jianzhi

Click here to view

Book Id: WPLBN0003931561
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : Evolution of Vertebrate Transient Receptor Potential Vanilloid 3 Channels ; Opposite Temperature Sensitivity Between Mammals and Western Clawed Frogs, Volume 7  
Author: Zhang, Jianzhi
Volume: Volume 7
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Zhang, J. (n.d.). Plos Genetics : Evolution of Vertebrate Transient Receptor Potential Vanilloid 3 Channels ; Opposite Temperature Sensitivity Between Mammals and Western Clawed Frogs, Volume 7. Retrieved from http://www.ebooklibrary.org/


Description
Description : Transient Receptor Potential (TRP) channels serve as temperature receptors in a wide variety of animals and must have played crucial roles in thermal adaptation. The TRP vanilloid (TRPV) subfamily contains several temperature receptors with different temperature sensitivities. The TRPV3 channel is known to be highly expressed in skin, where it is activated by warm temperatures and serves as a sensor to detect ambient temperatures near the body temperature of homeothermic animals such as mammals. Here we performed comprehensive comparative analyses of the TRPV subfamily in order to understand the evolutionary process: we identified novel TRPV genes and also characterized the evolutionary flexibility of TRPV3 during vertebrate evolution. We cloned the TRPV3 channel from the western clawed frog Xenopus tropicalis to understand the functional evolution of the TRPV3 channel. The amino acid sequences of the N- and C-terminal regions of the TRPV3 channel were highly diversified from those of other terrestrial vertebrate TRPV3 channels, although central portions were well conserved. In a heterologous expression system, several mammalian TRPV3 agonists did not activate the TRPV3 channel of the western clawed frog. Moreover, the frog TRPV3 channel did not respond to heat stimuli, instead it was activated by cold temperatures. Temperature thresholds for activation were about 16 uC, slightly below the lower temperature limit for the western clawed frog. Given that the TRPV3 channel is expressed in skin, its likely role is to detect noxious cold temperatures. Thus, the western clawed frog and mammals acquired opposite temperature sensitivity of the TRPV3 channel in order to detect environmental temperatures suitable for their respective species, indicating that temperature receptors can dynamically change properties to adapt to different thermal environments during evolution.

 

Click To View

Additional Books


  • Plos Genetics : Gli2 and Gli3 Localize t... (by )
  • Plos Genetics : Srebp Controls Oxygen-de... (by )
  • Plos Genetics : a Nuclear Calcium-sensin... (by )
  • Plos Genetics : B-cyclin, Volume 6 (by )
  • Plos Genetics : Two Evolutionary Histori... (by )
  • Plos Genetics : Proteomic Changes Result... (by )
  • Plos Genetics : Genome-wide Association ... (by )
  • Plos Genetics : Horizontal Transfer, Not... (by )
  • Plos Genetics : Mutability and Importanc... (by )
  • Plos Genetics : Leptotene, Volume 6 (by )
  • Plos Genetics : Exploring Microbial Dive... (by )
  • Plos Genetics : Heritable Change Caused ... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.