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Plos Genetics : Relative Burden of Large Cnvs on a Range of Neurodevelopmental Phenotypes, Volume 7

By Orr, Harry T.

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Book Id: WPLBN0003931813
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Genetics : Relative Burden of Large Cnvs on a Range of Neurodevelopmental Phenotypes, Volume 7  
Author: Orr, Harry T.
Volume: Volume 7
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

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Orr, H. T. (n.d.). Plos Genetics : Relative Burden of Large Cnvs on a Range of Neurodevelopmental Phenotypes, Volume 7. Retrieved from http://www.ebooklibrary.org/


Description
Description : While numerous studies have implicated copy number variants (CNVs) in a range of neurological phenotypes, the impact relative to disease severity has been difficult to ascertain due to small sample sizes, lack of phenotypic details, and heterogeneity in platforms used for discovery. Using a customized microarray enriched for genomic hotspots, we assayed for large CNVs among 1,227 individuals with various neurological deficits including dyslexia (376), sporadic autism (350), and intellectual disability (ID) (501), as well as 337 controls. We show that the frequency of large CNVs (.1 Mbp) is significantly greater for ID–associated phenotypes compared to autism (p = 9.58610211, odds ratio = 4.59), dyslexia (p = 3.81610218, odds ratio = 14.45), or controls (p = 2.75610217, odds ratio = 13.71). There is a striking difference in the frequency of rare CNVs (.50 kbp) in autism (10%, p = 2.461026, odds ratio = 6) or ID (16%, p = 3.55610212, odds ratio = 10) compared to dyslexia (2%) with essentially no difference in large CNV burden among dyslexia patients compared to controls. Rare CNVs were more likely to arise de novo (64%) in ID when compared to autism (40%) or dyslexia (0%). We observed a significantly increased large CNV burden in individuals with ID and multiple congenital anomalies (MCA) compared to ID alone (p = 0.001, odds ratio = 2.54). Our data suggest that large CNV burden positively correlates with the severity of childhood disability : ID with MCA being most severely affected and dyslexics being indistinguishable from controls. When autism without ID was considered separately, the increase in CNV burden was modest compared to controls (p = 0.07, odds ratio = 2.33).

 

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