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Plos One : Candidate Polymorphisms and Severe Malaria in a Malian Population, Volume 7

By Diemert, David, Joseph

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Book Id: WPLBN0003934680
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Candidate Polymorphisms and Severe Malaria in a Malian Population, Volume 7  
Author: Diemert, David, Joseph
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Publication Date:
Publisher: Plos


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Diemert, D. J. (n.d.). Plos One : Candidate Polymorphisms and Severe Malaria in a Malian Population, Volume 7. Retrieved from

Description : Malaria is a major health burden in sub-Saharan African countries, including Mali. The disease is complex, with multiple genetic determinants influencing the observed variation in response to infection, progression, and severity. We assess the influence of sixty-four candidate loci, including the sickle cell polymorphism (HbS), on severe malaria in a case-control study consisting of over 900 individuals from Bamako, Mali. We confirm the known protective effects of the blood group O and the HbS AS genotype on life-threatening malaria. In addition, our analysis revealed a marginal susceptibility effect for the CD40 ligand (CD40L)+220C allele. The lack of statistical evidence for other candidates may demonstrate the need for largescale genome-wide association studies in malaria to discover new polymorphisms. It also demonstrates the need for establishing the region-specific repertoire of functional variation in important genes, including the glucose-6-phosphatase deficiency gene, before embarking on focused genotyping.


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