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Plos One : Decrease of Mir-202-3P Expression, a Novel Tumor Suppressor, in Gastric Cancer, Volume 8

By Cho, William C S

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Book Id: WPLBN0003946273
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Decrease of Mir-202-3P Expression, a Novel Tumor Suppressor, in Gastric Cancer, Volume 8  
Author: Cho, William C S
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

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S Cho, W. C. (n.d.). Plos One : Decrease of Mir-202-3P Expression, a Novel Tumor Suppressor, in Gastric Cancer, Volume 8. Retrieved from http://www.ebooklibrary.org/


Description
Description : Emerging studies have indicated that microRNAs are involved in the development and progression of cancer. Here we found that miR-202-3p was frequently down-regulated in gastric cancer tissues. Overexpression of miR-202-3p in gastric cancer cells MKN-28 and BGC-823, markedly suppressed cell proliferation and induced cell apoptosis both in vitro and in vivo. Furthermore, Gli1 expression was frequently positive in gastric cancer tissues and inversely correlated with miR-133b expression. We demonstrate that the transcriptional factor Gli1 was a target of miR-202-3p and plays an essential role as a mediator of the biological effects of miR-202-3p in gastric cancer. MiR-202-3p also inhibited the expression of c-catenin and BCL-2. Taken together, these findings suggest that miR-202-3p may function as a novel tumor suppressor in gastric cancer and its anti-tumor activity may attribute the direct targeting and inhibition of Gli1.

 

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