World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Deferasirox and Vitamin D Improves Overall Survival in Elderly Patients with Acute Myeloid Leukemia After Demethylating Agents Failure, Volume 8

By Roemer, Klaus

Click here to view

Book Id: WPLBN0003946302
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Deferasirox and Vitamin D Improves Overall Survival in Elderly Patients with Acute Myeloid Leukemia After Demethylating Agents Failure, Volume 8  
Author: Roemer, Klaus
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Roemer, K. (n.d.). Plos One : Deferasirox and Vitamin D Improves Overall Survival in Elderly Patients with Acute Myeloid Leukemia After Demethylating Agents Failure, Volume 8. Retrieved from http://www.ebooklibrary.org/


Description
Description : The prognosis of acute myeloid leukemia (AML) in elderly ($65 years) patients is poor and treatment remains nonconsensual especially for those who are not eligible for intensive therapies. Our group has shown that in vitro the iron chelator deferasirox (DFX) synergizes with vitamin D (VD) to promote monocyte differentiation in primary AML cells. Herein, we present results from a retrospective case-control study in which the association of DFX (1–2 g/d) and 25- hydroxycholecalciferol (100,000 IU/week) (DFX/VD) was proposed to patients following demethylating agents failure. Median survival of patients treated with DFX/VD combination (n = 17) was significantly increased in comparison with matched patients receiving best supportive care (BSC) alone (n = 13) (10.4 versus 4 months respectively). In addition, the only factor associated to an increased overall survival in DFX/VD-treated patients was serum VD levels. We conclude that DFX/VD treatment correlated with increased overall survival of AML patients in this retrospective cohort of elderly patients.

 

Click To View

Additional Books


  • Plos One : Novel Fluorescein Angiography... (by )
  • Plos One : Local and Regional Determinan... (by )
  • Plos One : Sevoflurane Induces Endoplasm... (by )
  • Plos One : Deletion of the Fission Yeast... (by )
  • Plos One : Transplantation of Oligodendr... (by )
  • Plos One : Clinical Significance of Eml4... (by )
  • Plos One : Ecological Niche Modeling and... (by )
  • Plos One : Arresten, a Collagen-derived ... (by )
  • Plos One : Combining Traits and Density ... (by )
  • Plos One : Interspecific Variation in Co... (by )
  • Plos One : Enhanced Expression of Ano1 i... (by )
  • Plos One : Inhibition of the Differentia... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.